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ProteomicsSuperior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy
Polycystic ovary syndrome (PCOS) is a heterogeneous condition, of polyhedric pathogenesis and clinical presentation, defined by oligo-/anovulation, hyperandrogenism and/or polycystic ovaries. Metabolic complications are highly common also in patients suffering PCOS, including obesity, insulin resist...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD044134 | Pride
Pcos Glp1 Glp1/gip Glp1/gip/glucagon Glp1/e 
UnknownA broad and systematic approach to identify B cell malignancy-targeting TCRs for multi-antigen-based T cell therapy.
Not available
S-EPMC8821929 | biostudies-literature
GenomicsIL-18-secreting multi-antigen targeting CAR T-cells eliminate antigen-low myeloma in an immunocompetent mouse model [in vitro]
IL-18-secreting multi-antigen targeting CAR T-cells eliminate antigen-low myeloma in an immunocompetent mouse model [in vitro]
PRJNA1089207 | ENA
GenomicsIL-18-secreting multi-antigen targeting CAR T-cells eliminate antigen-low myeloma in an immunocompetent mouse model [in vivo]
IL-18-secreting multi-antigen targeting CAR T-cells eliminate antigen-low myeloma in an immunocompetent mouse model [in vivo]
PRJNA1034126 | ENA
ProteomicsSolubility based mechanistic profiling of combinatorial drug therapy
Acute myeloid leukemia (AML) poses a major clinical challenge due to its genetic diversity, relapse rates, and chemotherapy toxicity. While rational drug combinations improve efficacy, their mechanisms remain poorly understood. We introduce CoPISA (Proteome Integral Solubility/Stability Alteration A...
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD066812 | Pride
Combination therapy Acute myeloid leukaemia Proteome integral solubility alteration assay for combinations Copisa 
UnknownPreclinical efficacy of multi-targeting mRNA-based CAR T cell therapy in resection models of glioblastoma.
Not available
S-EPMC12397939 | biostudies-literature
UnknownMulti-targeting NGR-modified liposomes recognizing glioma tumor cells and vasculogenic mimicry for improving anti-glioma therapy.
Not available
S-EPMC5190048 | biostudies-literature
UnknownAdaptive multi-epitope targeting and avidity-enhanced nanobody platform for ultrapotent, durable antiviral therapy.
Not available
S-EPMC11748749 | biostudies-literature
GenomicsCAR-T cell therapy for chronic kidney disease
CAR-T cell therapy for chronic kidney disease
PRJNA1212718 | ENA
UnknownDevelopment of a successive targeting liposome with multi-ligand for efficient targeting gene delivery.
Not available
S-EPMC3461335 | biostudies-literature
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