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ProteomicsSuperior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy
Polycystic ovary syndrome (PCOS) is a heterogeneous condition, of polyhedric pathogenesis and clinical presentation, defined by oligo-/anovulation, hyperandrogenism and/or polycystic ovaries. Metabolic complications are highly common also in patients suffering PCOS, including obesity, insulin resist...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD044134 | Pride
Pcos Glp1 Glp1/gip Glp1/gip/glucagon Glp1/e 
GenomicsProfiling Genome-wide Chromatin Methylation with Engineered Posttranslation Apparatus within Living Cells
We have engineered the chromatin-modifying apparatus and formulated a novel technology, termed Clickable Chromatin Enrichment with parallel DNA sequencing (CliEn-seq), to probe genome-wide chromatin modification within living cells. Examine (E)-hex-2-en-5-ynylation mediated by engineered G9a Y1154A ...
ORGANISM(S): Homo sapiens 
2013-03-04 | E-GEOD-42792 | biostudies-arrayexpress
UnknownSuperior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy.
Not available
S-EPMC11445520 | biostudies-literature
UnknownRisks of peri- and postoperative complications with glucagon-like peptide-1 receptor agonists.
Not available
S-EPMC12051400 | biostudies-literature
GenomicsHomo sapiens
Profiling Genome-wide Chromatin Methylation with Engineered Posttranslation Apparatus within Living Cells
PRJNA183346 | ENA
UnknownAbdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes.
Not available
S-EPMC7731616 | biostudies-literature
ProteomicsPhosphoproteomics evaluation of the effect of GLP-1 on the porcine pacemaker
GLP-1 induces an increase in heart rate, but its mechanism remains elusive. We used a phosphoproteomic approach to evaluate the effect of GLP-1 on the porcine sinus node. Tissue samples from the sinus node region and left ventricle were collected from eight animals following a 60-minute infusion wit...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-06-10 | PXD042583 | Pride
Heart Phosphoproteomics Pig Pacemaker Glucagon-like peptide 1 Porcine Glp-1 Sinus node 
ProteomicsFunctional proteomics defines a PRC2-G9A interaction network and reveals ZNF518B as a G9A regulator
Not available
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2014-12-17 | MSV000078980 | MassIVE
TranscriptomicsComparing the transcriptome profiling of ob/ob mice treated with the GLP-1 receptor agonist liraglutide, a clinically used GLP-1 receptor agonist, versus baseline controls
B6.Cg-Lep ob/ob mice females were surgically implanted in an age of 10-12 weeks with Alzet osmotic mini pumps (model 1002, 0,25l/h, Cupertino, CA, USA) in two groups of ten mice each to perform continuous subcutaneous infusions of Dulbecco's phosphate buffered saline (vehicle; n = 8) or GLP-1 (GLP-1...
ORGANISM(S): Mus musculus 
2017-09-03 | E-MTAB-6015 | biostudies-arrayexpress
GenomicsChromatin Immunoprecipitation of TRA-1 in C. elegans and C. briggsae
The goal of this study is to identify and characterize sites in the C. elegans genome bound by the transcription factor TRA-1. TRA-1 ChIP-seq was performed in the following stages of animals in duplicate: 1) L2 stage of C. elegans wild-type N2 strain; 2) L3 stage of C. elegans wild-type N2 strain; 3...
ORGANISM(S): Caenorhabditis briggsae 
2013-11-04 | E-GEOD-48917 | biostudies-arrayexpress
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