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MetabolomicsMolecular basis for multidrug efflux by an anaerobic-associated RND transporter

Bacteria can resist antibiotics and toxic substances within demanding ecological settings, such as low oxygen, extreme acid, and during nutrient starvation. MdtEF, a proton motive force-driven efflux pump from the resistance-nodulation-cell division (RND) superfamily, is upregulated in these cond...

2025-09-26 | MTBLS13050 | MetaboLights
MetabolomicsATP-binding Cassette Sub-family C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs
The ubiquitous efflux transporter ATP-binding cassette sub-family C member 5 (ABCC5) is present at high levels in the blood-brain barrier, neurons and glia, but its function is not known. Untargeted metabolomic screens revealed that Abcc5-/- mice accumulate endogenous glutamate conjugates in several...
2015-11-02 | MTBLS197 | MetaboLights
MetabolomicsA female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite
ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. The genome of the human malaria parasite, Plasmodium falciparum, encodes multiple members of this family, one of which, gABCG2, is transcribed predominantly in the gametoc...
2016-09-14 | MTBLS98 | MetaboLights
TranscriptomicsTranscriptional profiling of orf19.5100/MLT1 ABC transporter knockout in Candida albicans
Recent reports have been suggested involvement of ABC transporters in various physiological roles.To get better insight about possible involvement of vacuolar ABC transporter MLT1/orf19.5100 in different physiological roles transcriptional profiling have been peformed and compared between WT(SC5314...
ORGANISM(S): Candida albicans 
2016-07-25 | E-GEOD-70341 | biostudies-arrayexpress
TranscriptomicsNext generation RNA sequencing to identify overexpressed transporter genes in Zymoseptoria tritici field strains
Septoria leaf blotch is a worldwide threat for wheat and mainly controlled by the application of synthetic fungicides. The fungal pathogen responsible for this disease, Zymoseptoria tritici, was shown as highly adaptable to its host plant, but also to fungicide challenge. Over the past decades it de...
ORGANISM(S): Zymoseptoria tritici 
2015-06-10 | E-GEOD-58672 | biostudies-arrayexpress
ProteomicsBidirectional signaling between nucleotide and substrate binding sites in a type IV multidrug ABC transporter
ATP-binding cassette (ABC) transporters use ATP to transport substrates across cellular membranes. In type IV ABC transporters, which includes many multidrug resistance (MDR) pumps, communication between the nucleotide-binding domains (NBDs) and transmembrane domains (TMDs) occurs via intracellular ...
ORGANISM(S): Escherichia coli 
2025-11-13 | PXD058013 | Pride
Bmra Hdx-ms Lc-msms Multidrug transporter 
ProteomicsSuppressed Protein Translation Caused by MSP-8 Defect Determines Fungal Multidrug Resistance with Fitness Cost
Antifungal resistance, particularly the rise in multidrug resistance, has become a critical public health concern, garnering substantial attention. In this study, we used experimental evolution with Neurospora crassa as a model and identified a novel multidrug-resistance gene, msp-8, which encodes a...
ORGANISM(S): Neurospora Crassa Or74a 
2024-08-02 | PXD054574 |
ProteomicsStructural insights into the catalytic cycle of a bacterial multidrug ABC efflux pump
ABC (“ATP-Binding Cassette”) exporters of the type IV subfamily gather transporters involved in the efflux of many compounds and notably those capable to confer multidrug resistance like the mammalian P-glycoprotein or the bacterial transporter BmrA. They function according to an alternating access ...
ORGANISM(S): Bacillus subtilis 
2022-03-24 | PXD028663 | Pride
Multidrug resistance Hydrogen-deuterium exchange ms Abc transporter Bmra 
TranscriptomicsA role for Multidrug Resistance Protein 4 (MRP4; ABCC4) in human Dendritic Cell migration.
The capacity of dendritic cells (DC) to migrate from peripheral organs to lymph nodes (LN) is an important event in the initiation of a T cell-mediated immune response. Previously it was shown that the ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp; ABCB1) and the 2 multidrug resistanc...
ORGANISM(S): Homo sapiens 
2008-07-12 | E-GEOD-12089 | biostudies-arrayexpress
TranscriptomicsLmrR Lactococcus lactis MG1363
Comparison of L. lactis NZ9000 ?lmrR versus L. lactis NZ9000 wild type Keywords: Transcription profiling Comparison between strain lacking transcriptional regulator LmrR of major Lactococcal mdr transporter LmrCD, and wild type parental strain.
ORGANISM(S): Lactococcus lactis subsp. cremoris MG1363 
2007-10-04 | E-GEOD-9168 | biostudies-arrayexpress
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