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TranscriptomicsIdentification of the Early VIP Transriptome and its Associated Interactome in Resting Murine CD4 T Cells
Identification of the Early Vasoactive Intestinal Peptide (VIP) Transriptome and its Associated Interactome in Resting Murine CD4 T Cells In an attempt to understand the biological role of this neuropeptide in the immune system, we choose CD4 T cells as a cellular system for identifying a VIP-indu...
ORGANISM(S): Mus musculus 
2010-01-09 | E-GEOD-18524 | biostudies-arrayexpress
TranscriptomicsIdentification of the Early VIP Transriptome and its Associated Interactome in Activated Murine CD4 T Cells
Identification of the Early Vasoactive Intestinal Peptide (VIP) Transriptome and its Associated Interactome in Activated Murine CD4 T Cells In an attempt to understand the biological role of this neuropeptide in the immune system, we choose CD4 T cells as a cellular system for identifying a VIP-in...
ORGANISM(S): Mus musculus 
2010-01-09 | E-GEOD-18525 | biostudies-arrayexpress
TranscriptomicsIdentification of the Early VIP Transriptome and its Associated Interactome in Resting and Activated Murine CD4 T Cells
This SuperSeries is composed of the following subset Series: GSE18524: Identification of the Early VIP Transriptome and its Associated Interactome in Resting Murine CD4 T Cells GSE18525: Identification of the Early VIP Transriptome and its Associated Interactome in Activated Murine CD4 T Cells Refer...
ORGANISM(S): Mus musculus 
2010-01-09 | E-GEOD-18526 | biostudies-arrayexpress
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsGenerating mouse model with predominant naïve or innate memory phenotype CD4+ T cells
Innate memory phenotype (IMP) CD4+ T cells are non-conventional αβ T cells exhibiting features of innate immune cells, characterized as CD44high and CD62Llow in periphery. It is recently reported by our group that bone marrow chimeric mice lacking thymic MHCI expression develop predominantly IMP C...
ORGANISM(S): Mus musculus 
2014-03-14 | E-GEOD-46892 | biostudies-arrayexpress
TranscriptomicsNon-alcoholic steatohepatitis causes selective CD4+ T cell loss and promotes hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the second most common cause of cancer related death. NAFLD affects a large proportion of the US population. Its incidence and prevalence are increasing to epidemic proportions around the world and is known to increase the risk of HCC. We studied how intrahepatic li...
ORGANISM(S): Mus musculus 
2016-03-10 | E-GEOD-67918 | biostudies-arrayexpress
ProteomicsThe NuRD complex is required for Thpok-mediated CD4+ T cell development
This data represent characterization of the interactome of murine Thpok. A version of Thpok (Thpok-Bio) subject to biotinylation in vivo by the BirA biotin ligase was used; to assess Thpok interactions in primary cells, Thpok-Bio was retrovirally expressed in in vitro activated CD4+ T cells from Thp...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000088126 | MassIVE
TranscriptomicsSystematic RNA-seq analysis of the early events of CD4+ T cell activation
RNA-seq was used to look at the transcriptome changes and the early events of T cell receptor stimulation in CD4+ T cells CD4+ T cells were stimulated with immobilised anti-CD3/CD28 antibodies for 4 hours and RNA was extracted and subjected to RNA-seq analysis.
ORGANISM(S): Mus musculus 
2012-08-08 | E-GEOD-34550 | biostudies-arrayexpress
ProteomicsProteomics and network analyses reveals inhibition of Akt-mTOR signaling in CD4+ T cells by Mycobacterium tuberculosis Mannose-capped Lipoarabinomannan
CD4+ T cells have a central role in controlling Mtb infection (1). Despite immune control, Mtb persists by interfering with macrophage and T cell function, allowing for pathogen survival. Our group has demonstrated direct and indirect inhibition of CD4+ T cell activation by different Mtb molecules i...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-05 | PXD004164 | Pride
Lc/ms/ms Mycobacterium tuberculosis mannose-capped lipoarabinomannan Pathway analysis Label free proteomics 
ProteomicsLC-MS analysis of Murine eIF4E-BP1/2 Double Knockout naive and TCR stimulated CD4+ T cells
This project focuses on examining the differences in the global CD4+ T cell proteome between cells lacking the negative regulators of eIF4E( eIf4E-Binding Proteins 1/2) and WT naive CD4+ T cells both prior and following TCR stimulation.
ORGANISM(S): Mus musculus (Mouse) 
2023-05-20 | PXD039635 | Pride
Translational regulation Immunology Cd4+ t cells Murine Eif4e 
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