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TranscriptomicsTranscriptomic analysis of vulvovaginal candidiasis identifies a role for the NLRP3 inflammasome
RNA-seq analysis of an in vivo murine model of vulvovaginal candidiasis Murine vaginas were infected with Candida albicans and harvested for RNA-seq analysis 3 days post-infection
ORGANISM(S): Mus musculus 
2015-04-11 | E-GEOD-67688 | biostudies-arrayexpress
TranscriptomicsNLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells
Effect of Monosodium Urate Crystals in wild-type and NLRP3 ko murine dendritic cells
ORGANISM(S): Mus musculus 
2013-07-11 | E-MEXP-3858 | biostudies-arrayexpress
ProteomicsTyrosine Phosphorylation of NLRP3 by Src Family Protein Tyrosine Kinase Lyn Suppresses NLRP3 Inflammasome Activation
The NLRP3 inflammasome is a multi-protein complex that triggers the activation of the inflammatory protein caspase-1 and the maturation of the cytokine IL-1 in response to microbes and other danger signals in host cells. Here, we sought a deeper understanding of how the NLRP3 inflammasome is regulat...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD028582 | Pride
Lyn tryosine kinase Murine nlrp3 inflammasome 
ProteomicsThe Ragulator complex regulates NLRP3 inflammasome activation through interaction with HDAC6
The activation of the NLRP3 inflammasome is spatiotemporally orchestrated by various organelles, but the precise roles of lysosomes are still unclear. Here we show the vital role of the Ragulator complex, a lysosomal protein, in NLRP3 inflammasome activation. Deficiency of Lamtor1, an essential comp...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD033497 | Pride
Ragulator complex Hdac6 Nlrp3 inflammasome Α-tocopherol 
GenomicsmicroRNA Expression Changes in Organotin-Driven NLRP3 Inflammasome Activation in Murine Bone Marrow Derived Macrophages
microRNA Expression Changes in Organotin-Driven NLRP3 Inflammasome Activation in Murine Bone Marrow Derived Macrophages
PRJNA648754 | ENA
GenomicsmRNA Expression Changes in Organotin-Driven NLRP3 Inflammasome Activation in Murine Bone Marrow Derived Macrophages
mRNA Expression Changes in Organotin-Driven NLRP3 Inflammasome Activation in Murine Bone Marrow Derived Macrophages
PRJNA648753 | ENA
ProteomicsA cereblon-based (CRBN) glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner
Aberrant NLRP3 inflammasome activation is linked to many inflammatory diseases, driving the search for therapeutics inhibiting this pathway. NEK7 is proposed to mediate NLRP3 inflammasome assembly and activation by bridging adjacent NLRP3 subunits. Hence, reduction of NEK7 protein may block NLRP3 ac...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-06-18 | PXD057229 | Pride
Molecular glue degrader Inflammation Nek7 Nlrp3 inflammasome Crbn 
ProteomicsDDX3X SUMOylation Promotes Septic Inflammation by Enhancing NLRP3 Inflammasome Activation
This study investigates the role of DDX3X SUMOylation in the activation of the NLRP3 inflammasome during sepsis. We demonstrate that SUMOylation of DDX3X, regulated by the SUMO protease SENP1, is a crucial trigger for NLRP3 inflammasome activation. In endotoxemia and sepsis models, the absence of SE...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-06 | PXD060598 | Pride
Lc-ms 
GenomicsSTING mediates hepatocyte pyroptosis in liver fibrosis via epigenetic activating NLRP3 inflammasome
STING mediates hepatocyte pyroptosis in liver fibrosis via epigenetic activating NLRP3 inflammasome
PRJNA898611 | ENA
GenomicsmicroRNA Expression Changes in Organotin-Driven NLRP3 Inflammasome Activation in Murine Bone Marrow Derived Macrophages
Trimethyltin (TMT) and triethyltin (TET) are two tri-organotin compounds, a group of substances reported to affect mitochondria function. These compounds were also found to activate the NLRP3 inflammasome, an inflammatory cascade that occurs in myeloid cells when primed with a Toll-like receptor lig...
ORGANISM(S): synthetic construct Mus musculus 
2021-05-05 | GSE155127 | GEO
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