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ProteomicsHigh-throughput Proteomics fiber typing (ProFiT) for comprehensive characterization of single skeletal muscle fibers
Skeletal muscles are composed of a heterogeneous collection of fiber types with different physiological adaption in response to a stimulus and disease-related conditions. Each fiber has a specific molecular expression of myosin heavy chain molecules (MyHC). So far MyHCs are currently the best marker...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-02 | PXD017755 | Pride
Muscle fiber proteomics Protein turnover Phosphoproteomics Myhc profiling 
ProteomicsSingle muscle fiber proteomics reveals fiber type-specific features of human muscle aging
Skeletal muscle is a key tissue in human aging, which affects different muscle fiber types unequally. We developed a highly sensitive single muscle fiber proteomics workflow to study human aging and show that the senescence of slow and fast muscle fibers is characterized by diverging metabolic and p...
ORGANISM(S): Homo sapiens (Human) 
2017-06-14 | PXD006182 | Pride
Muscle fibers Skeletal muscle Aging 
ProteomicsSingle muscle fiber proteomics reveals remodeling of focal adhesions in response to muscle unloading and microgravity
Spaceflight causes loss of muscle mass and strength, metabolic remodeling and insulin resistance, contributing to severe challenges for astronaut health. We used highly sensitive proteomics to detail single fiber type-specific molecular remodeling caused by muscle unloading in subjects undergoing pr...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028435 | Pride
Proteomics Microgravity Muscle 
ProteomicsProteomics of slow and fast human muscle fibers reveals extensive fiber type-specific adaptations in response to exercise training
Skeletal muscle plays an important role in the health-promoting effects of exercise training, yet the underlying mechanisms are not fully elucidated. Proteomics of skeletal muscle is challenging due to presence of non-muscle tissues and existence of different fiber types confounding the results. Thi...
ORGANISM(S): Homo sapiens (Human) 
2020-12-21 | PXD012824 | Pride
Transcription Mitochondrial biogenesis Mhc Glycogen Glucose metabolism Proteome Fiber type 
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
ProteomicsAdvanced fiber type-specific protein profiles derived from adult murine skeletal muscle
Skeletal muscle is a heterogeneous tissue consisting of blood vessels, connective tissue, and muscle fibers. The last are highly adaptive and can change their molecular composition depending on external and internal factors, such as exercise, age, and disease. Thus, examination of the skeletal muscl...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-07 | PXD025359 | Pride
Laser microdissection Proteomics Neuromuscular disorders Skeletal muscle Fiber types 
ProteomicsGadd45a Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4
Skeletal muscle atrophy is a serious and highly prevalent condition that remains poorly understood at the molecular level. Previous work found that skeletal muscle atrophy involves an increase in skeletal muscle Gadd45a expression, which is necessary and sufficient for skeletal muscle fiber atrophy...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-05-17 | MSV000079730 | MassIVE
ProteomicsMuscle fiber proteomics reveals sex- and fiber type-specific adaptations to resistance training
Skeletal muscle hypertrophy is a hallmark of resistance training that positively impacts health and longevity. However, despite physiological differences between sexes and fiber types, the underlying proteome changes with resistance training have not been studied in a sex- and fiber type-specific ma...
ORGANISM(S): Homo sapiens (Human) 
2026-09-10 | PXD056664 | Pride
ProteomicsMuscle proteomics of mitochondrial disorders
Mitochondrial DNA mutations progressively compromise the respiratory chain of skeletal muscle, resulting in a mosaic of metabolically healthy and defective fibers. This heterogeneity is the best diagnostic signpost of mitochondrial disorders. However, the single fiber investigation of its molecular...
ORGANISM(S): Homo sapiens (Human) 
2019-11-15 | PXD010489 | Pride
Laser microdissection Single muscle fibers Q exactive hf Human muscle Mitochondrial disorders 
ProteomicsProteomics analysis of skeletal muscle from leptin-deficient ob/ob mice reveals adaptive remodeling of metabolic characteristics and fiber type composition
Skeletal muscle insulin resistance, an early metabolic defect in the pathogenesis of type 2 diabetes, may be a cause or consequence of altered protein expressions profiles. Proteomics technology offers enormous promise to investigate molecular mechanisms underlying pathologies, however, the analysis...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-26 | PXD007697 | Pride
Mouse skeletal muscle Obesity C2c12 muscle cells Lcmsms Diabetes 
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