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ProteomicsQuantitative proteomics and phosphoproteomics analysis revealed different regulatory mechanisms of Halothane and Rendement Napole genes in porcine muscle metabolism
Pigs with the Halothane (HAL) and Rendement Napole (RN) gene mutations have different muscle energy metabolism patterns. It is not completely understood how HAL and RN mutations regulate glucose and energy metabolism in muscle. In order to investigate potential signaling pathways and phosphorylation...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2018-06-21 | PXD008292 | Pride
Porcine muscle  rn and hal mutation  muscle metabolism  glycogen metabolism  camk2  phosphoproteomics 
ProteomicsThe genetic and dietary landscape of the muscle insulin signalling network
Using mass spectrometry-based phosphoproteomics, we quantified 23,126 phosphosites in the skeletal muscle of five genetically distinct inbred mouse strains exposed to two controlled dietary environments, with and without acute insulin treatment. Almost half of the insulin-regulated phosphoproteome w...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-21 | PXD041229 | Pride
Phosphoproteomics Glucose regulation Phosphoproteome Diet Environment Genetic Skeletal muscle Mouse 
ProteomicsTargeted exercise enhances functional integration of engineered muscle grafts after volumetric muscle loss
Damage that affects large volumes of skeletal muscle tissue can severely impact health, mobility, and quality-of-life. Efforts to restore muscle function by implanting engineered grafts at the site of damage have demonstrated limited restoration of force production. Various forms of mechanical and b...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD039237 | Pride
Engineered muscle graft Muscle phosphoproteomics Volumetric muscle loss 
ProteomicsThe exercise-regulated skeletal muscle phosphoproteome
Four healthy male volunteers (age: 24 - 27; BMI: 24.2 - 25.9 kg/m2) underwent a single bout of high-intensity bicycle exercise reaching a VO2 max approximately 95% with blood samples and muscle biopsies taken immediately pre- and post-exercise. Subjects reached 95% VO2 max in approximately 9 to 12 m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080777 | MassIVE
ProteomicsAdaptation-dependent alterations in the human skeletal muscle proteome and phosphoproteome of human skeletal muscle in response to damaging resistance exercise
Resistance exercise (RE) enhances strength, muscle mass, and overall health. Intense RE also triggers rapid muscle damage that is efficiently restored through proteostatic mechanisms in healthy individuals. However, the specific factors and signalling processes active at sites of damage remain poorl...
ORGANISM(S): Homo sapiens (Human) 
2026-04-28 | PXD044976 | Pride
Resistance exercise Proteomics Adaptation Fractionation Human muscle Phosphoproteomics Deadaptation 
ProteomicsPersonalized phosphoproteomics of skeletal muscle insulin resistance and exercise links MINDY1 to insulin action
Insulin resistance, the defective regulation of glucose metabolism by insulin, increases the risk of type 2 diabetes and cardiovascular disease. It is not yet known how insulin resistance remodels signalling networks in human tissues. Here, we define the signalling architecture of insulin resistance...
ORGANISM(S): Homo sapiens (Human) 
2024-11-22 | PXD032948 | Pride
Insulin resistance Proteomics Post-translational modification Mass spectrometry Exercise Skeletal muscle Signal transduction Phosphorylation Phosphoproteomics Human 
ProteomicsPhosphoproteomics of rodent exercise models
Exercise stimulates systemic and tissue-specific adaptations that protect against lifestyle related diseases including obesity and type 2 diabetes. Exercise places high mechanical and energetic demands on contracting skeletal muscle, which require finely-tuned protein post-translational modification...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2019-07-22 | PXD010452 | Pride
Skeletal muscle Signal transduction Exercise Phosphoproteomics 
ProteomicsPhosphopeptide-analysis in ALS muscle
Phosphoproteomics of muscle biopsies from ALS-patients and healthy controls.
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD055632 | Pride
Phospho Muscle Als 
ProteomicsProteomic and phosphoproteomic of C18ORF25 KO skeletal muscle following electrical contraction
We recently identified C18ORF25 as a new exercise-regulated phophoprotein. To investigate potential in vivo functions of C18ORF25, we used CRISPR/Cas9 to generate a whole-body knock-out (KO) mouse model on a C57BL/6J background. Proteomic analysis was performed to identify potental changes in the pr...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-18 | PXD031101 | Pride
Proteomics Electrical contraction C18orf25 Skeletal muscles Phosphoproteomics 
ProteomicsPhosphoproteomic analysis of three exercise modalities in human skeletal muscle
To characterize phosphorylation-based signaling events across different exercise modalities we subjected eight healthy young men (age, 26.3±1.3 years; BMI, 23.5±0.7 kg/m2; maximal oxygen uptake (VO2 max), 42.6±1.5 ml/kg/min) that did not perform regular physical activity apart from local bicycling t...
ORGANISM(S): Homo sapiens (Human) 
2022-07-18 | PXD031049 | Pride
Skeletal muscle Phosphoproteomics Exericse 
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