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MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
MetabolomicsLinking gastrointestinal microbiota and metabolome dynamics to clinical outcomes in pediatric hematopoietic stem cell transplantation

BACKGROUND: Hematopoietic stem cell transplantation is a curative procedure for a variety of conditions. Despite major advances, a plethora of adverse clinical outcomes can develop post-transplantation including graft-versus-host disease and infections, which remain the major cau...

2022-05-11 | MTBLS4065 | MetaboLights
MetabolomicsSemaglutide targets muscle mitochondria to regulate osteoarthritis

Metabolic and inflammatory diseases often coexist, and become important challenges facing global health, and obesity has shown to be a susceptibility factor for osteoarthritis (OA). As a metabolic regulatory drug for lowering blood sugar and body weight, semaglutide has shown additional therapeut...

2026-05-06 | MTBLS14059 | MetaboLights
MetabolomicsExercise-Associated Microbial Metabolites Prevent Skeletal Muscle Atrophy in Adult Mice
We previously reported that skeletal muscle adaptation to regular exercise requires a healthy gut microbiome, contributing to growing evidence that some exercise benefits are mediated by microbiome-derived metabolites. Here, to identify such exercise-associated microbial metabolites, we transfer cec...
2026-05-27 | MTBLS14386 | MetaboLights
MetabolomicsSemaglutide targets muscle mitochondria to regulate glutamine metabolism and treat osteoarthritis

Metabolic and inflammatory diseases often coexist, and become important challenges facing global health, and obesity has shown to be a susceptibility factor for osteoarthritis (OA). As a metabolic regulatory drug for lowering blood sugar and body weight, semaglutide has shown additional therapeut...

2026-05-06 | MTBLS14295 | MetaboLights
MetabolomicsGut-Muscle Axis Regulates Meat Quality in Lambs: Rumen Microbiota-Differentiated L-Arginine and Serotonin Signaling Mediates Muscle Lipid Remodeling

This study investigated age-associated changes in the gut-muscle axis and their potential contribution to meat quality in Tan sheep (Ovis aries). Twelve Tan sheep were divided into two age groups, including six 3-month-old animals (T3) and six 6-month-old animals (T6). Untargeted LC-MS metabolomi...

2026-09-03 | MTBLS15419 | MetaboLights
TranscriptomicsMicroRNA expression profiling of quiescent and activated muscle stem cells
MicroRNA expression profiling during muscle stem cell activation. Quiescent muscle stem cells from uninjured muscles and activated muscle stem cells from injured muscles at indicated time points were isolated by FACS. MicroRNA expression profiling during muscle stem cell activation using real-time ...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-26780 | biostudies-arrayexpress
TranscriptomicsFungenES: FunGenES_UKOE-4: Functional characterization and transcriptome analysis of embryonic stem cells-derived contractile smooth muscle cells
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the EuropeanUnion, http://www.fungenes.org). The experiment was conducted at University of Cologne, Cologne, Germany. Goal of the experiment is a...
ORGANISM(S): Mus musculus 
2011-02-25 | E-TABM-1123 | biostudies-arrayexpress
TranscriptomicsProfiling of mouse muscle stem cells aging and activation upon skeletal muscle injury
Utilizing glycerol intramuscular injections in M. musculus provide a models of skeletal muscle damage followed by skeletal muscle regeneration. In particular, glycerol-induced muscle injury triggers accute activation of skeletal muscle stem cells, called satellite cells. However, aging dramatically ...
ORGANISM(S): Mus musculus 
2016-07-04 | E-GEOD-81096 | biostudies-arrayexpress
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