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ProteomicsMUT-7 exoribonuclease activity and localisation are mediated by an ancient domain
The MUT-7 family of 3’-5’ exoribonucleases is evolutionarily conserved across the animal kingdom and plays essential roles in small RNA production in the germline. Most MUT-7 homologs carry a C-terminal domain of unknown function named MUT7 C appended to the exoribonuclease domain. Our analysis show...
ORGANISM(S): Escherichia coli Caenorhabditis elegans 
2024-10-17 | PXD048205 | Pride
Mut7-c Mut-7 Rde-2 Mut-8 Mutator complex 
UnknownNovel c.2216T > C (p.I739T) mutation in exon 13 and c.1481T > A (p.L494X) mutation in exon 8 of MUT gene in a female with methylmalonic acidemia.
Not available
S-EPMC3756855 | biostudies-literature
TranscriptomicsTranscriptomics analysis of gene expression in wildtype and foxo1 synonymous mutated mouse liver
The selected gRNA sequence is tggcatgtttattgagcgctTGG. To disrupt the demethylation motif RRACT in 2288-2290 of Foxo1 mRNA (NM_019739), a mutation (ttGGACT to ctCGATT) target vector was constructed with 1214bp 5’arm and 849bp 3’arm. Mouse zygotes obtained by mating of males with superovulated C57BL/...
ORGANISM(S): Mus musculus 
2022-01-26 | GSE125786 | GEO
UnknownMulti-scale simulations of MUT-16 scaffold protein phase separation and client recognition.
Not available
S-EPMC12709416 | biostudies-literature
UnknownFunctional Characterization and Drug Response of Freshly Established Patient-Derived Tumor Models with CpG Island Methylator Phenotype.
Not available
S-EPMC4664421 | biostudies-literature
UnknownElbamycellarosea gen. et sp. nov. (Juncigenaceae, Torpedosporales) isolated from the Mediterranean Sea.
Not available
S-EPMC6595004 | biostudies-literature
Unknownmut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.
Not available
S-EPMC3029761 | biostudies-literature
TranscriptomicsGenes regulated by the winged helix transcription factor Rfx6 in adult beta cell in the mouse
The goal of this study was to identify genes which are differentiatlly expresesd upon induced inactivation of Rfx6 in beta cell in adult mice Rfx6fl/fl; Ins1-CreERT2 (mut) and Rfx6fl/fl (ctrl) 8 weeks old mice were injected subcutaneously with tamoxifen daily during 3 days. Pancreatic islets were ...
ORGANISM(S): Mus musculus 
2014-12-11 | E-GEOD-59622 | biostudies-arrayexpress
UnknownPIK3CA co-occurring mutations and copy-number gain in hormone receptor positive and HER2 negative breast cancer.
Not available
S-EPMC8857304 | biostudies-literature
TranscriptomicsNutlin-3 treatment of B-CLL
Background: p53 plays a key role in determining the clinical features of B cell chronic lymphocytic leukemia (CLL). Disruption of p53 by point mutations, deletion at 17p13, or both, occurs in a fraction of cases at diagnosis and predicts poor survival and chemorefractoriness. In cells with functiona...
ORGANISM(S): Homo sapiens 
2009-11-11 | GSE18971 | GEO
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