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MetabolomicsMetabolomic changes in Mycobacterium avium subsp. paratuberculosis (MAP) challenged Holstein-Friesian cattle suggest the role of serum amino acids as indicators of immune system activation

INTRODUCTION: Paratuberculosis, commonly known as Johne’s disease, is a chronic intestinal infection of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). Clinical signs, including reduced milk yields, weight loss and diarrhoea, are typically abse...

2022-02-23 | MTBLS2963 | MetaboLights
TranscriptomicsMycobacterium avium subsp. paratuberculosis gene transcription in simulated phagosomal environment and in human macrophage infection
This SuperSeries is composed of the following subset Series: GSE32241: Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro acid-nitrosative multi-stress GSE32242: Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculos...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2012-05-31 | E-GEOD-32243 | biostudies-arrayexpress
TranscriptomicsBovine Peyer's Patch Infected with Mycobacterium avium ssp. paratuberculosis and Mycobacterium avium ssp. avium
Mycobacterium avium subspecies paratuberculosis (MAP) infection is established following the ingestion of bacteria, their penetration of the intestinal mucosa and subsequent events of the host-parasite interaction. These bacteria invade M cells, macrophages and are capable of resisting host defenses...
ORGANISM(S): Bos taurus 
2012-10-03 | E-GEOD-13888 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of whole-blood in Mycobacterium avium subsp. paratuberculosis-infected cattle
To provide novel insights into understanding the host-immune response during the different stages of progression of the disease, we performed gene expression profiling in Mycobacterium avium subsp. paratuberculosis infection in cattle. We analyzed the transcriptional profiles of whole-blood cells of...
ORGANISM(S): Bos taurus 
2014-10-31 | E-GEOD-62835 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridizations of Mycobacterium avium isolates obtained from multiple host species
A comparative genomic approach was used to identify large sequence polymorphisms among Mycobacterium avium isolates obtained from a variety of host species. DNA microarrays were used as a platform for comparing mycobacteria field isolates with the sequenced bovine isolate Mycobacterium avium subsp....
ORGANISM(S): Mycobacterium avium 
2010-06-11 | E-GEOD-7622 | biostudies-arrayexpress
ProteomicsIdentification of immunoreactive proteins of Mycobacterium avium subsp. Paratuberculosis
Mycobacterium avium subsp. paratuberculosis (MAP) is the cause of a chronic enteritis of ruminants (bovine paratuberculosis-Johne disease) that is associated with enormous worldwide economic losses for the zootechnical industries. Diagnosis is based on observation of clinical signs, on the detection...
ORGANISM(S): Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) Other Actinobacteria (class) 
2014-11-20 | PXD001159 | Pride
Mycobacterium avium subsp. paratuberculosis  johne’s disease  immunoreactive proteins  soil biological contaminant 
TranscriptomicsDifferentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro acid-nitrosative multi-stress
Transcriptional profile of Mycobacterium avium subspecies paratuberculosis in in vitro acid-nitrosative multistress, comparing untreated control cells and bacteria under multi-stress. Two-condition experiment, MAP-K vs. MAP-ACID-NO treated. Biological replicates: 3 controls, 3 Acid-NO treated, indep...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2012-05-31 | E-GEOD-32241 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Mycobacterium avium subsp. paratuberculosis cattle and sheep strains grown under in vitro iron limiting or iron sufficient conditions
Transcriptional responses of two strain types of Mycobacterium avium subsp. paratuberculosis (MAP, cattle and sheep Strain) under in vitro iron limiting or iron sufficient growth conditions. Background: In MAP, the transcriptional role and essentiality of MAP2827 (IdeR) as an iron dependent regulato...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2010-10-31 | E-MEXP-2865 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Mycobacterium avium subsp. paratuberculosis K-10 within macrophage cell line
Once entering the cell, M. avium subsp.paratuberculosis is known to survive harsh microenvironments, especially those inside activated macrophages. To improve our understanding of M. avium subsp.paratuberculosis pathogenesis, we examined the phagosome maturation associated with transcriptional resp...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis K-10 
2013-01-22 | E-GEOD-43645 | biostudies-arrayexpress
TranscriptomicsDifferentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro infection of THP-1 human macrophage cell line
Transcriptional profile of Mycobacterium avium subspecies paratuberculosis in in vitro THP-1 (ATCC TIB-202) cell line infection, comparing bacteria grown in host medium and intracellular bacteria recovered from infected THP-1 cells. Two-condition experiment, MAP-K vs. intracellular MAP-THP-1. Biolog...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2012-05-31 | E-GEOD-32242 | biostudies-arrayexpress
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