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UnknownPentapeptide boronic acid inhibitors of Mycobacterium tuberculosis MycP1 protease.
Not available
S-EPMC4120117 | biostudies-literature
GenomicsTranscriptional profile of Mycobacterium tuberculosis mycP1-eccE1 deletion mutant
Transcriptional profile of Mycobacterium tuberculosis mycP1-eccE1 deletion mutant
PRJNA489657 | ENA
ProteomicsSecretome and intracellular proteome of eccE1 and mycP1 deletion mutants of Mycobacterium tuberculosis
Mycobacterium tuberculosis uses the specialised ESX-1 secretion system to secrete virulence factors and potent immunogenic effectors required for disease progression. ESX-1 is a multi-subunit apparatus with a membrane complex that is predicted to form a pore in the cytoplasmic membrane. In M. tuberc...
ORGANISM(S): Mycobacterium tuberculosis 
2019-12-16 | PXD012584 | Pride
Esx-1 Mycobacterium tuberculosis Ecce1 Mycp1 
UnknownUnderstanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis.
Not available
S-EPMC3859186 | biostudies-literature
ProteomicsProteolytic-independent role of mycosins in stabilization of the ESX-1 and ESX-5 type VII secretion membrane complexes.
Pathogenic mycobacteria contain up to five type VII secretion (T7S) systems, ESX-1 to ESX-5, which have central roles in virulence and viability. One of the conserved components of these systems, the serine protease mycosin (MycP), has been shown to be essential for secretion by ESX-1 and ESX-5. How...
ORGANISM(S): Mycobacterium marinum ATCC BAA-535 
2016-10-11 | PXD003766 | Pride
Mycobacterium marinum Tuberculosis Esx1 Single-shot Esx5 Label-free T7s 
TranscriptomicsTranscriptional profile of Mycobacterium tuberculosis mycP1-eccE1 deletion mutant
Mycobacterium tuberculosis is a slow-growing intracellular bacterium with the ability to induce host cell death and persist indefinitely in the human body. This pathogen uses the specialised ESX-1 secretion system to secrete virulence factors and potent immunogenic effectors required for disease pro...
ORGANISM(S): Mycobacterium tuberculosis 
2019-09-01 | GSE119582 | GEO
UnknownStructure of the mycosin-1 protease from the mycobacterial ESX-1 protein type VII secretion system.
Not available
S-EPMC3682577 | biostudies-literature
UnknownMycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes.
Not available
S-EPMC5082899 | biostudies-literature
UnknownApplication of the 4D fingerprint method with a robust scoring function for scaffold-hopping and drug repurposing strategies.
Not available
S-EPMC4210175 | biostudies-literature
UnknownStructure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis.
Not available
S-EPMC4520771 | biostudies-literature
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