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TranscriptomicsPKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized not only by neuronal loss and synaptic dysfunction but also by emerging evidence of oligodendrocyte and myelin pathology. Amyloid-β (Aβ), a hallmark of AD, disrupts oligodendrocyte homeostasis through mechanisms that remain poorly understood. Here, we invest...
ORGANISM(S): Mus musculus 
2025-12-31 | E-MTAB-16400 | biostudies-arrayexpress
ProteomicsMyelin proteome alterations upon oligodendroglial deletion of CDC42 and its effector proteins CDC42EP1/CDC42EP2
The regular structure of healthy CNS myelin sheaths requires specialized structural proteins, including septin filaments composed of subunits SEPTIN2, SEPTIN4, SEPTIN7, and SEPTIN8. Their assembly scaffolds the innermost non-compacted myelin layer as a late step of CNS myelin maturation and their di...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-30 | PXD066943 | Pride
Label-free protein quantification White matter Cytoskeleton Oligodendrocyte Septins Mass spectrometry Myelination Myelin pathology Myelin proteome 
GenomicsGPR34 senses myelin debris to promote neuroinflammation and pathology
GPR34 senses myelin debris to promote neuroinflammation and pathology
PRJNA802043 | ENA
ProteomicsProteome profile of peripheral myelin in healthy mice and in a neuropathy model
Using the sciatic nerve as a model, we biochemically purified peripheral nervous system (PNS) myelin and systematically assessed its proteome by dedicated, partly ion mobility-enhanced data-independent acquisition (DIA) workflows with alternating low and elevated energy (MSE) modes. Specifically, we...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-20 | PXD015960 | Pride
Transcriptome Axon degeneration Mouse Dynamic range enhancement Peripheral nervous system (pns) Charcot-marie-tooth disease Label-free quantification Myelin proteome Neuropathy Demyelination 
GenomicsT cell mediated microglia activation triggers myelin pathology in a model of amyloidosis
T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis
PRJNA1015730 | ENA
ProteomicsWhite matter integrity requires continuous myelin synthesis at the inner tongue
Myelin, the electrically insulating axonal sheath, is composed of lipids and proteins with exceptionally long lifetime. Using 3D electron microscopy, mass spectrometry imaging, and quantitative proteome analysis, we addressed the question how myelin function is affected by myelin turnover. We studie...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-14 | PXD025180 | Pride
Shiverer Myelin basic protein (mbp) Myelinoid body Juxtaparanode Myelin turnover Whole optic nerve proteome Optic nerve Fib-sem 3d reconstruction Nanosims 
UnknownMyelin phagocytosis by astrocytes after myelin damage promotes lesion pathology.
Not available
S-EPMC5841057 | biostudies-literature
GenomicsT cell mediated microglia activation triggers myelin pathology in a model of amyloidosis [MERFISH]
T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis [MERFISH]
PRJNA1016407 | ENA
UnknownImpaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex.
Not available
S-EPMC5697648 | biostudies-literature
GenomicsPKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer’s disease
PKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer’s disease
PRJEB105554 | ENA
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