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TranscriptomicsTranscriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils
The role of myeloid cells in supporting cancer growth is well established. Most work has focused on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, but tumor-associated neutrophils (TAN) are also known to be capable of augmenting tumor growth. However, little is kno...
ORGANISM(S): Mus musculus 
2013-01-04 | E-GEOD-43254 | biostudies-arrayexpress
ProteomicsIdentification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes
Recently, we have shown that after partial hepatectomy (PHx), an increased hepatic blood flow initiates liver growth in mice by vasodilation and mechanically-triggered release of angiocrine signals. Here, we use mass spectrometry to identify a mechanically-induced angiocrine signal in human hepatic ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-28 | PXD033942 | Pride
Human Lc-ms-ms Myeloid-derived growth factor Liver 
TranscriptomicsmiRNA expression in myeloid-derived suppressor cells (MDSCs) treated with or without whole ?-glucan particles (WGP)
Murine MDSCs isolated from the spleens of Lewis lung carcinoma mice were treated with or without WGP, and then miRNA array was used to analyze the differentailly expressed miRNAs. Murine MDSCs were isolated from the spleens of Lewis lung carcinoma tumor-bearing mice, and the sorted MDSCs were stimul...
ORGANISM(S): Mus musculus 
2015-06-26 | E-GEOD-67578 | biostudies-arrayexpress
TranscriptomicsMolecular and cellular characterization of Cord Blood derived, IDO expressing human fibrocystic Myeloid Derived Suppressor Cells
By restraining T cell activation and promoting regulatory T cell (Treg) expansion, myeloid-derived suppressor cells (MDSC) and tolerogenic dendritic cells (DC) (tDC) can control self-reactive and anti-graft effector T cells in autoimmunity and transplantation. Their therapeutic use and characterizat...
ORGANISM(S): Homo sapiens 
2014-08-26 | E-GEOD-52376 | biostudies-arrayexpress
TranscriptomicsTumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism
Global gene expression studies were performed to determine whether the granulocytic-like MDSC populations from G-CSF treated mice resembled those of tumor-bearing (TB) mice more so than those of the non-tumor-bearing control (i.e., WT) at a molecular level. Splenic CD11b+Gr-1high cell populations fr...
ORGANISM(S): Mus musculus 
2011-12-07 | E-GEOD-32209 | biostudies-arrayexpress
TranscriptomicsLow-density miRNA microarray of induced mouse myeloid-derived suppressor cell
Myeloid-derived suppressor cells (MDSCs) are one of the main cell populations that negatively regulate immune responses. However, the mechanism underlying the differentiation and expansion of MDSCs remains unclear. Employing a low-density miRNA microarray and a TaqMan probe-based qRT-PCR assay, we ...
ORGANISM(S): Mus musculus 
2014-03-11 | E-GEOD-50914 | biostudies-arrayexpress
TranscriptomicsHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Acute phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. U...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-22009 | biostudies-arrayexpress
GenomicsMyeloid Derived Growth Factor is an endogenous, paracrine regulator of neutrophil activation and confined motility
Myeloid Derived Growth Factor is an endogenous, paracrine regulator of neutrophil activation and confined motility
PRJNA1331544 | ENA
TranscriptomicsExpression data from bone marrow derived- and tumor induced- CD11b+ MDSC
Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF...
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-21927 | biostudies-arrayexpress
TranscriptomicsHomogeneous monocytes and macrophages from hES cells following coculture-free differentiation in M-CSF and IL-3.
In the present study we aimed at producing homogeneous populations of monocytes and macrophages from human embryonic stem (hES) cells. Human embryonic stem cell lines KCL001, KCL002, and HUES-2 were differentiated into monocytes by coculture-free differentiation with two growth factors using a three...
ORGANISM(S): Homo sapiens 
2010-05-08 | E-GEOD-15791 | biostudies-arrayexpress
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