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ProteomicsA Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway
The Hedgehog (Hh) signaling pathway is fundamental to embryogenesis, tissue homeostasis, and cancer. Hh signals are transduced via an unusual mechanism: upon agonist-induced phosphorylation, the noncanonical G protein-coupled receptor SMOOTHENED (SMO) binds the catalytic subunit of protein kinase A ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD067578 | Pride
Smoothened Protein kinase a Hedgehog 
ProteomicsSmoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits
The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein-coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription facto...
ORGANISM(S): Homo Sapiens 
PXD023893 | panorama
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