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TranscriptomicsTranscriptome analysis of zebrafish mononuclear myogenic cells (zMNCs) during myogenic differentiation
Analysis of the transcriptome of zebrafish mononuclear myogenic cells (zMNCs) during myogenic differentiation. The main goal is to identify the similarities of zMNC myogenic differentiation with that of mammalian myoblast differentiation. Critical time points were used to identify a switch from the ...
ORGANISM(S): Danio rerio 
2010-04-07 | E-GEOD-19754 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of siRNA Knock-Down of Six1, Six4 and Myogenin in C2C12
Six1, Six4 and Myogenin are transcription factors that are known to be required for skeletal myogenesis. Currently, very little is known about the genes targeted by Six1 and Six4. Gene expression profiling when one or both transcription factors were knock-down by siRNA was performed to identify gene...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-19967 | biostudies-arrayexpress
TranscriptomicsmiR-487b, miR-3963 and miR-6412 delayed myogenic differentiation in C2C12 mouse myoblast-derived cells.
We newly identified skeletal muscle differentiation-associated miRNAs by comparing miRNA expression profile between C2C12 cell and Wnt4-overexpressing C2C12 cell. miR-487b, miR-3963 and miR-6412 are significantly down-regulated in differentiating C2C12 cells, and transfection of their mimics result...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-63454 | biostudies-arrayexpress
TranscriptomicsWnt signaling involved in mouse myoblast differentiation
Wnt/M-NM-2-catenin signaling is involved in various aspects of skeletal muscle development and regeneration. In addition, Wnt3a and M-NM-2-catenin are required for muscle-specific gene transcription in embryonic carcinoma cells and satellite-cell proliferation during adult skeletal muscle regenerati...
ORGANISM(S): Mus musculus 
2011-07-15 | E-GEOD-30077 | biostudies-arrayexpress
ProteomicsSNAIL is a key regulator of rhabdomyosarcoma progression and myogenic differentiation
Rhabdomyosarcoma (RMS) is a frequent non-epithelial tumor of soft tissue that originates from a myogenic differentiation defect. Expression of SNAIL transcription factor is elevated in the alveolar subtype of RMS, characterized by a low myogenic differentiation status and high aggressiveness. SNAIL ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD006711 | Pride
Snail (snai1) Myod Myomirs Myogenic differentiation Rhabdomyosarcoma (rms) Myf5 Metastasis 
TranscriptomicsDistant cis Regulation of Myogenic Differentiation
Identifying tissue and condition-specific gene regulatory elements and the mechanisms by which they associate with their target genes in human cells remains a significant challenge, largely due to the vast amount of non-protein-coding sequence in the human genome. Despite increasing evidence of phys...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-29865 | biostudies-arrayexpress
TranscriptomicsGenomic mapping of Six1 binding sites during skeletal myoblast differentiation
In this study, the C2C12 cell line, a model used to study myogenesis and regeneration, was allowed to differentiate from myoblast precursor cells to myotubes. Cells were harvested at 3 different timepoints to perform ChIP-on-Chip of Six1, which is a key muscle regulator. We identified global loci bo...
ORGANISM(S): Mus musculus 
2010-07-05 | E-GEOD-20150 | biostudies-arrayexpress
TranscriptomicsExpression profiling of 4q-linked and phenotypic FSHD in different steps of myogenic differentiation
The specific gene(s) responsible for FSHD phenotype have not yet been identified. We used the Human GeneChip Exon 1.0 ST platform to analyze the global gene expression profiles of FSHD-1, FSHD-2 and controls during myogenic differentiation. In this dataset, we include the expression data of human pr...
ORGANISM(S): Homo sapiens 
2011-07-07 | E-GEOD-26061 | biostudies-arrayexpress
GenomicsGenome-wide remodeling of the epigenetic landscape during myogenic differentiation
We have examined changes in the chromatin landscape during muscle differentiation by mapping the genome-wide location of ten key histone marks and transcription factors in mouse myoblasts and terminally differentiated myotubes, providing an exceptionally rich dataset that has enabled discovery of ke...
ORGANISM(S): Mus musculus 
2011-05-08 | E-GEOD-25308 | biostudies-arrayexpress
GenomicsDynamic loss of H2B ubiquitylation without corresponding changes in H3K4 tri-methylation during myogenic differentiation
Ubiquitylation of H2B on lysine 120 (H2Bub) is associated with active transcriptional elongation. H2Bub has been implicated in histone cross-talk and is generally regarded to be a prerequisite for H3K4 and H3K79 tri-methylation in both yeast and mammalian cells. We performed a genome-wide analysis o...
ORGANISM(S): Mus musculus 
2012-03-06 | E-GEOD-34960 | biostudies-arrayexpress
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