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ProteomicsFilaminC pull-down experiment from myotube lysates
This project was designed to identify a difference in the binding affinity of FILIP1 to different FLNc variants. To this end FLNc domain 1-3 and FLNc d18-21 were used as bait for a pull-down analysis.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-05-25 | PXD017670 | Pride
Pull-down Myotube lysate Flnc 
ProteomicsDissection of the cellular function of the ZBED6 transcription factor in mouse myoblast cells, IGF2-GGCT Lysate
The transcription factor ZBED6 acts as a repressor of Igf2 and affects directly or indirectly the transcriptional regulation of thousands of genes. Here, we use gene editing in mouse C2C12 myoblasts and show that ZBED6 regulates Igf2 exclusively through its binding site 5′-GGCTCG-3′ in intron 1 of I...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-07 | PXD012789 | Pride
Zbed6 Silac Igf2 Mitochondria Myogenesis 
ProteomicsDissection of the cellular function of the ZBED6 transcription factor in mouse myoblast cells, ZBED6-KO Lysate
The transcription factor ZBED6 acts as a repressor of Igf2 and affects directly or indirectly the transcriptional regulation of thousands of genes. Here, we use gene editing in mouse C2C12 myoblasts and show that ZBED6 regulates Igf2 exclusively through its binding site 5′-GGCTCG-3′ in intron 1 of I...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-07 | PXD012757 | Pride
Zbed6 Silac Igf2 Mitochondria Myogenesis 
UnknownIdentification and Quantification of Murine Mitochondrial Proteoforms Using an Integrated Top-Down and Intact-Mass Strategy.
Not available
S-EPMC6201694 | biostudies-literature
ProteomicsInterplay between cultured human osteoblastic and skeletal muscle cells: Effects of conditioned media on glucose and fatty acid metabolism
The interplay between skeletal muscle and bone is primarily mechanical, however, biochemical crosstalk by secreted mediators has recently gained increased attention. The aim of this study was to investigate metabolic effects of conditioned medium from osteoblasts (OB-CM) on myotubes and vice versa. ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045723 | Pride
Energy metabolism  myokines  osteoblastic cells  osteokines  primary human myotubes 
UnknownManufacturing autologous myoblast for regenerative medicine applications.
Not available
S-EPMC7547920 | biostudies-literature
TranscriptomicsThe Histone Variant MacroH2A1.2 is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1
Histone variants complement and integrate histone post-translational modifications in regulating transcription. The histone variant macroH2A1 (mH2A1) is almost three times the size of its canonical H2A counterpart due to the presence of a ~25kDa evolutionarily conserved non-histone macro domain. Str...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-76010 | biostudies-arrayexpress
GenomicsMaster Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes [ChIP-Seq]
The master transcription factors Oct4, Sox2 and Nanog bind enhancer elements and recruit the Mediator co-activator to activate much of the gene expression program of embryonic stem cells (ESCs). We report here that the ESC master transcription factors and Mediator form “super-enhancers” at most gene...
ORGANISM(S): Mus musculus 
2013-02-13 | E-GEOD-44286 | biostudies-arrayexpress
TranscriptomicsLocal translational program at the muscle-tendon junction endows domain identity in muscle syncytia - Riboseq
Skeletal muscle fibers are large multinucleated cells that form specialized subdomains such as the neuromuscular and myotendinous junctions (MTJ), the latter connecting muscle to tendon and transmitting contractile force. While transcriptional heterogeneity among myonuclei is established, the contri...
ORGANISM(S): Mus musculus 
2026-09-30 | E-MTAB-16304 | biostudies-arrayexpress
TranscriptomicsCell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2011-08-24 | E-GEOD-21621 | biostudies-arrayexpress
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