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ProteomicsGlobal profiling and inhibition of protein lipidation in vector and host stages of the sleeping sickness parasite Trypanosoma brucei via chemical proteomics
The enzyme N-myristoyltransferase (NMT) catalyses the essential fatty acylation of substrate proteins with myristic acid in eukaryotes and is a validated drug target in the parasite Trypanosoma brucei, the causative agent of African trypanosomiasis (sleeping sickness). N-Myristoylation typically med...
ORGANISM(S): Trypanosoma brucei 
2016-05-17 | PXD004053 | Pride
Target validation N-myristoylation Chemical proteomics Human african trypanosomiasis Click chemistry Protein lipidation 
ProteomicsValidation and invalidation of chemical probes for the human N-myristoyltransferases.
On-target, cell-active chemical probes are of fundamental importance in both chemical and cell biology, whereas the application of poorly-characterised probes often leads to invalid conclusions. Human N-myristoyltransferase (NMT) has attracted increasing interest as a target in cancer and infectious...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD012722 | Pride
N-myristoylation Imp-366 (ddd85646) Metabolic tagging Tris-dba palladium Myristic acid alkyne ynmyr Chemical proteomics Imp-1088 D-nmappd (b13) 2-hydroxymyristic acid 
ProteomicsBi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive complex movement disorders
The acyl-CoA-binding domain-containing protein 6 (ACBD6) is ubiquitously expressed, plays a role in the acylation of lipids and proteins, and regulates the N-myristoylation of proteins via N-myristoyltransferase enzymes (NMTs). However, its precise function in cells is still unclear, as is the conse...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD024957 | Pride
N-myristoylation Metabolic tagging Myristic acid alkyne ynmyr Chemical proteomics Imp-1088 Acbd6 
ProteomicsIdentification of myristoylated proteins in Human cell lines (HEK293, HeLa, MCF7)
Multi-functional capture reagents reported here enable robust identification of metabolically-tagged myristoylated proteomes with unprecedented confidence resulting from the combination of chemical probe-based enrichment, and release and direct detection of lipid-modified peptides by MS. Whilst capt...
ORGANISM(S): Homo sapiens (Human) 
2015-03-30 | PXD001863 | Pride
Human Protein myristoylation Chemical probes Myristoylated peptides Lc-ms/ms 
ProteomicsIdentification of myristoylated proteins in zebrafish (Danio rerio)
Multi-functional capture reagents reported here enable robust identification of metabolically-tagged myristoylated proteomes with unprecedented confidence resulting from the combination of chemical probe-based enrichment, and release and direct detection of lipid-modified peptides by MS. Whilst capt...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2015-03-30 | PXD001876 | Pride
Protein myristoylation Chemical probes Zebrafish Myristoylated peptides Lc-ms/ms 
ProteomicsQuantitative lipoproteomics in Clostridium difficile reveals a role for lipoproteins in sporulation
Bacterial lipoproteins are surface exposed, anchored to the membrane by S diacylglyceryl modification of the N-terminal cysteine thiol. They play important roles in many essential cellular processes including, in bacterial pathogens, at the host-pathogen interface. Clostridium difficile is a Gram-po...
ORGANISM(S): Peptoclostridium difficile (strain R20291) (Clostridium difficile) Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2022-03-02 | PXD002426 | Pride
R20291 Ynmyr Lipoproteome Clostridium difficile 630 Peptoclostridium difficile 
UnknownBi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders.
Not available
S-EPMC10994533 | biostudies-literature
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