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UnknownDesign and Characterization of Myristoylated and Non-Myristoylated Peptides Effective against Candida spp. Clinical Isolates.
Not available
S-EPMC8875392 | biostudies-literature
ProteomicsIdentification of myristoylated proteins in Human cell lines (HEK293, HeLa, MCF7)
Multi-functional capture reagents reported here enable robust identification of metabolically-tagged myristoylated proteomes with unprecedented confidence resulting from the combination of chemical probe-based enrichment, and release and direct detection of lipid-modified peptides by MS. Whilst capt...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080690 | MassIVE
ProteomicsIdentification of myristoylated proteins in zebrafish (Danio rerio)
Multi-functional capture reagents reported here enable robust identification of metabolically-tagged myristoylated proteomes with unprecedented confidence resulting from the combination of chemical probe-based enrichment, and release and direct detection of lipid-modified peptides by MS. Whilst capt...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2015-03-30 | PXD001876 | Pride
Protein myristoylation Chemical probes Zebrafish Myristoylated peptides Lc-ms/ms 
ProteomicsIdentification of myristoylated proteins in Human cell lines (HEK293, HeLa, MCF7)
Multi-functional capture reagents reported here enable robust identification of metabolically-tagged myristoylated proteomes with unprecedented confidence resulting from the combination of chemical probe-based enrichment, and release and direct detection of lipid-modified peptides by MS. Whilst capt...
ORGANISM(S): Homo sapiens (Human) 
2015-03-30 | PXD001863 | Pride
Human Protein myristoylation Chemical probes Myristoylated peptides Lc-ms/ms 
UnknownMolecular basis for presentation of N-myristoylated peptides by the chicken YF1∗7.1 molecule.
Not available
S-EPMC12212280 | biostudies-literature
ProteomicsIdentification of protein-protein interaction mediated by N-myristoylated proteins using photocrosslinkable clickable myristoylation probes X3 and X10
HeLa cells were treated with myristoylation probes X3 and X10, which incorporate both alkyne and diazirine moieties. Cells were then treated with NMT ihibitor IMP-366 (DDD85464) or DMSO vehicle and UV-irradiated before lysis. The experiment identifies myristoylated proteins through comparison of veh...
ORGANISM(S): Homo sapiens (Human) 
2023-02-04 | PXD029944 | Pride
Diazirine Nmt Photocrosslinking Myristoylaion 
UnknownCrystal structure of the N-myristoylated lipopeptide-bound MHC class I complex.
Not available
S-EPMC4735555 | biostudies-literature
ProteomicsProteomic analysis of the anticancer effect of an antimicrobial myristoylated peptide
Antimicrobial peptides (AMPs),bioactive against multidrug-resistant (MDR) human pathogens, are promising candidates to counteract the antimicrobial resistance. Strong efforts are in progress to bring AMPs into clinical use and they are also being investigated as anticancer agents. In this context, w...
ORGANISM(S): Homo sapiens (Human) 
2026-05-06 | PXD074461 | Pride
Proteomics Cancer therapies Myristoilated peptides Cancer cells Antimicrobial peptides 
ProteomicsQuantitative TMT proteomics of myristoylated proteins in Trypanosoma cruzi and human cardiomyocytes during N-myristoyltransferase inhibition
This project investigates the impact of N-myristoyltransferase (NMT) inhibition on the myristoylated proteome of Trypanosoma cruzi and human cardiomyocytes in the context of Chagas disease. Human AC16 cardiomyocytes were infected with T. cruzi (CL Brener strain) and treated with the reference NMT in...
ORGANISM(S): Trypanosoma cruzi Homo sapiens (Human) 
2026-01-26 | PXD071927 | Pride
N-myristoyltransferase N-myristoylation Tmt sixplex Orbitrap exploris 240 Chagas disease Ac16 cardiomyocytes Trypanosoma cruzi Click chemistry Quantitative proteomics Lc–ms/ms 
ProteomicsGlobal profiling of myristoylation in Toxoplasma gondii
N-myristoylation is a ubiquitous class of protein lipidation across eukaryotes and N-myristoyl transferase (NMT) has been proposed as an attractive drug target in several pathogens. Here we describe the first global chemoproteomic analysis of protein myristoylation in Toxoplasma gondii. Through quan...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2020-07-06 | PXD019677 | Pride
N-myristoylation Chemical proteomics Toxoplasma Nmt inhibition 
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