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MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
UnknownWearable sensors for Parkinson's disease: which data are worth collecting for training symptom detection models.
Not available
S-EPMC6550186 | biostudies-literature
ProteomicsPhosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration
This study sought to explore phosphoproteome signaling dysregulation in different models of neurodegeneration. We collected phosphotyrosine, MAPK/CDK substrates, global phosphoproteome, and protein expression data from hippocampus and/or cortex tissue from each model. Tryptic peptides were multiplex...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-09 | PXD018757 | Pride
Tau p301s Siglec-f Mouse 5xfad Bv-2 Phosphotyrosine Alzheimer's disease Ck-p25 Lc-ms/ms 
UnknownAutomated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients.
Not available
S-EPMC8126790 | biostudies-literature
UnknownUnderstanding income-related differences in distribution of child growth, behaviour and development using a cross-sectional sample of a clinical cohort study.
Not available
S-EPMC8852748 | biostudies-literature
GenomicsThe Genomic Analysis of Medulloblastoma

Medulloblastoma is a heterogenous disease made up of at least four distinct subtypes of disease which appear to exploit and disrupt naturally occurring developmental pathways of cellular growth and hindbrain development. To better understand the driver mutations of this disease, we performed whol...

phs000409.v1.p1 | EGA
MetabolomicsTargeting PI3K inhibitor resistance in breast cancer with metabolic drugs

Activating PIK3CA mutations, present in up to 40% of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (Her2-) breast cancer (BC) patients, can be effectively targeted with the alpha isoform-specific PI3K inhibitor Alpelisib. This treatment significantly improves ...

2026-08-21 | MTBLS11671 | MetaboLights
UnknownLow-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial.
Not available
S-EPMC3934929 | biostudies-literature
TranscriptomicsNovel mutations target distinct subgroups of medulloblastoma.
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups. To identify mutations that drive medulloblastoma we sequenced the entire genomes of 37 tumours and matched normal blood. One hundred and thirty-six genes harbouring somatic mutations in this discovery set wer...
ORGANISM(S): Homo sapiens 
2012-07-05 | E-GEOD-37418 | biostudies-arrayexpress
UnknownThe Effects of Cinacalcet in Older and Younger Patients on Hemodialysis: The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial.
Not available
S-EPMC4422239 | biostudies-literature
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