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TranscriptomicsGenome-wide analysis of renal gene expression during hyperoxaluria development
Previous studies have proposed that production of reactive oxygen species (ROS) is an important contributor to renal injury and inflammation following exposure to oxalate or calcium-oxalate crystals. The present study was conducted to determine, utilizing global transcriptome analyses, if the NADPH...
ORGANISM(S): Rattus norvegicus 
2012-12-20 | E-GEOD-36446 | biostudies-arrayexpress
TranscriptomicsThe plasma membrane NADPH oxidase OsRbohA plays a crucial role in developmental regulation and drought-stress response in rice
Plasma membrane NADPH oxidases (NOXs) are major producers of reactive oxygen species (ROS) in plant cells under normal growth and stress conditions. Rice NOXs have multiple homologs but their functional mechanisms are largely unknown. We used microarrays to detail the global gene expression profiles...
ORGANISM(S): Oryza sativa Japonica Group 
2015-12-31 | E-GEOD-54466 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse expressing non-cleavable transmembrane mutant form of murine TNFalpha, or treated with soluble TNFalpha (20ng/ml) for 4 hours to investigate divergent and convergent effects on gene expression and function in acute versus chronic endothelial activation
Activation of the vascular endothelium with cytokines such as TNF is widely used to study the role of the vasculature in proinflammatory disease. To gain insight into mechanisms of prolonged vascular endothelial activation we compared changes in gene expression induced by continuous activation in st...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-4518 | biostudies-arrayexpress
ProteomicsEROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling.
The phagocyte NADPH oxidase is critical for host defence, and EROS (Essential for Reactive Oxygen Species) protein is indispensable for expression of its gp91phox-p22phox heterodimer. EROS deficiency in humans is a recently described cause of chronic granulomatous disease (CGD), but its mechanism of...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-30 | PXD025149 | Pride
Nox family Inflammasome Nadph oxidase Ost complex Chaperone T cells P2x receptor Er 
ProteomicsNADPH Oxidase 1 in Chronic Pancreatitis-Activated Pancreatic Stellate Cells Facilitates the Progression of Pancreatic Cancer
Aims: Patients suffering from chronic pancreatitis (CP) have a higher risk of pancreatic ductal adenocarcinoma (PDAC). NADPH oxidase 1 (Nox1) in activated pancreatic stellate cells from a CP mouse model (CP-activated PaSCs) forms fibrotic tissue and up-regulates matrix metalloproteinase (MMP) 9. Yet...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD034177 | Pride
Nadph oxidase 1  mmp-9  peroxiredoxin  twist1  p38 mapk  pancreatic stellate cells 
UnknownHemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase.
Not available
S-EPMC3095934 | biostudies-literature
UnknownNADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.
Not available
S-EPMC2746760 | biostudies-literature
UnknownNADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox.
Not available
S-EPMC3048665 | biostudies-literature
UnknownNADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages.
Not available
S-EPMC5969376 | biostudies-literature
UnknownMolecular insights of p47phox phosphorylation dynamics in the regulation of NADPH oxidase activation and superoxide production.
Not available
S-EPMC4132782 | biostudies-literature
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