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TranscriptomicsGene expression profile upon forced Notch1 activation in LS174T cells
The cell line was modified to express activated form of Notch1 (NICD1 of mouse origin) upon Doxycycline addition to the culture medium generated by T-rex system (invitrogen) following manufacturer's instruction. Keywords: Genetic modification Pulse-chase experiment, examining expression profile at ...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10136 | biostudies-arrayexpress
GenomicsGenome-wide analysis of intracellular notch1(ICN1) targets in gamma delta T cells (gd T cells).
We performed chromatin immunoprecipitation followed by high-throughput DNA sequencing (ChIP-seq) for ICN1 in thymic gd T cells from neonates of C57BL/6 mice. Sequence reads for ICN1 and Input were aligned with the mouse reference genome (mm10) by bowtie program (v1.0.0), and peak detection and ident...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-56756 | biostudies-arrayexpress
TranscriptomicsExpression data from heterotopically grafted mouse small intestinal epithelium and the normal colonic epithelium
Epithelia of small and large intestines differ in their structures and functions. Such heterogeneity between these two epithelial tissues might be controlled by both epithelium-intrinsic and -extrinsic programs. By employing the cell transplantation technique developed in our laboratory, we investig...
ORGANISM(S): Mus musculus 
2014-08-15 | E-GEOD-59410 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression in the kidneys and testes of mice after low-dose-rate irradiation
Measuring global gene expression using cDNA or oligonucleotide microarrays is an effective approach to understanding the complex mechanisms of the effects of radiation. However, few studies have been carried out that investigate gene expression in vivo after prolonged exposure to low-dose-rate radia...
ORGANISM(S): Mus musculus 
2009-05-27 | E-GEOD-14290 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of LT-HSCs and ST-HSCs conditionally expressing MLL-ENL
We have developed a new conditional transgenic mouse showing that MLL-ENL, at an endogenous-like expression level, induces leukemic transformation selectively in LT-HSCs. To investigate the molecular mechanism of leukemic transformation in LT-HSCs conditionally expressing MLL-ENL, we preliminarily p...
ORGANISM(S): Mus musculus 
2013-07-17 | E-GEOD-48539 | biostudies-arrayexpress
ProteomicsDetermination of GPI structure of human CD59 in various KO CHO cells
To determine GPI structure of human CD59 in PGAP4-KO, PGAP3-KO, PGAP5-KO, and PGAP2-KO CHO cells.
ORGANISM(S): Homo sapiens (Human) 
2018-01-30 | PXD008230 | Pride
Lc-msms Cd59 Pgap5 Pgap4 Cho cells Pgap3 Gpi Pgap2 
ProteomicsDetermination of disulfide bridges of human PGAP4 protein
To determine disulfide bonds of human PGAP4 protein
ORGANISM(S): Homo sapiens (Human) 
2018-01-30 | PXD008137 | Pride
Lc-msms Disulfide bridges Pgap4 
ProteomicsGlycoproteomic analysis of fucose-containing proteins in small intestine identified cryptdin-related sequence 1 as O-glycosylated proteins modified with α1,2-fucose
The modification of galactose with α1,2-fucose is involved in symbiosis with intestinal bacteria and elimination of pathogenic bacteria. It is postulated that α1,2-fucosylated mucin secreted from goblet cells is involved in defending an organism against infections, but the detailed molecular mechani...
ORGANISM(S): Mus Musculus (mouse) 
2020-11-05 | PXD022132 | JPOST Repository
TranscriptomicsATAC-seq data in mouse and zebrafish limbs
Assay for Transposable Accessible Chromatin (ATAC) reveals a genome wide view of areas of open chromatin at very high resolution, which are often associated with regulatory activity. The ATAC-seq technology uses a Tn5 transposase loaded with nex-generation sequencing primers in order to simultaneous...
ORGANISM(S): Mus musculus 
2015-01-06 | E-GEOD-61065 | biostudies-arrayexpress
TranscriptomicsChromatin structure dynamics of hoxa13a, hoxa13b and hoxd13a loci during zebrafish development.
We designed 4C-Seq experiments for hoxa13a, hoxa13b and hoxd13a promoters in three developmental stages in zebrafish embryos: 24, 48 and 60 hpf. 4C-seq samples for three different hox13 genes promoters in three developmental stages in zebrafish embryos: 24, 48 and 60 hpf.
ORGANISM(S): Danio rerio 
2015-01-06 | E-GEOD-61063 | biostudies-arrayexpress
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