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TranscriptomicsGene expression pattern in CXCR4+ and CXCR4- subpopulation of breast cancer cells
The goal of this study was to identify signalling molecules downstream of CXCR4 in breast cancer cells. For this purpose, we sorted CXCR4-positive and CXCR4-negative cells from MDA-MB-231 breast cancer cell line by flow cytometry and performed microarrays analysis. Three sets of samples, each in qua...
ORGANISM(S): Homo sapiens 
2010-04-28 | E-GEOD-15893 | biostudies-arrayexpress
TranscriptomicsAKT Isoform Specificity Downstream of PIK3CA Mutation Impacts Estradiol and PI3K Inhibitor Response in Breast Cancer Cells
Background: PIK3CA mutations are observed in >30% of breast cancers, which are more common in estrogen receptor (ERα)-positive breast cancer compared with ERα-negative breast cancer. AKT1, 2, and 3 isoforms, major isoforms downstream of PI3K, modulate ERα activity. It is unknown whether PIK3CA mu...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-60759 | biostudies-arrayexpress
TranscriptomicsGenes differentailly expressed in organ-specific metastatic cells derived from MDA-MB-231 breast cancer cell line
Breast cancer metastasizes to bone, visceral organs, and/or brain depending on the subtypes. Various cell line models have been used to develop gene expression signatures unique to cancer cells that have metastasized to specific organs, although these efforts were not in a uniform setting. In this s...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-66495 | biostudies-arrayexpress
ProteomicsTumor tissue collection and processing under physioxia allows highly relevant detection of signaling networks and drug sensitivity of cancer cells
Preclinical studies of primary cancer cells are always done after tumors are removed from patients or animals at ambient atmospheric oxygen (O2, ~21%). However, O2 concentrations in organs are in the ~3-10% range, with most tumors in an hypoxic or 1-2% O2 environment in vivo. Although effects of O2 ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD023133 | Pride
Mouse Tumor Lc-ms/ms 
ProteomicsMechanisms associated with systemic effects of cancer
Cancer is considered as a disease of a specific organ, but its effects are felt throughout the body. The systemic effects of cancer can lead to weakness in muscles and heart, which hastens cancer-associated death. miR-486 is a myogenic microRNA and its reduced expression in skeletal muscle is observ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD028554 | Pride
Breast cancer Lc-msms Mouse Functional limitations Skeletal muscle Mir-486 
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