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MetabolomicsBifidobacterium bifidum-derived nanoparticles attenuate alcoholic liver disease via enhanced hepatic phagocytosis and gastrointestinal homeostasis
Alcohol-associated liver disease (ALD) has limited therapeutic options due to its complex pathogenesis. This study demonstrates the ALD-protective effects of extracellular nanoparticles derived from Bifidobacterium bifidum (BNPs), focusing on the novel concept of gut microbiota-derived nanoparticles...
2025-06-19 | MTBLS12612 | MetaboLights
ProteomicsMesoporous Silica Nanoparticles-based Formulations for Enhanced Oral Delivery of Peptide Drugs: a Case Study on Insulin
Peptide drugs have revolutionized modern medicine owing to their high potency, selectivity, and excellent tolerability. However, oral delivery remains limited, and most peptide drugs are administered parenterally due to their inherent instability to proteolytic digestion and poor ability to cross ga...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD074176 | Pride
Mesoporous silica nanoparticles (msn)  peptide delivery  peptide drugs  proteomics Insulin 
GenomicsEngineering Human PEG10-based Nanoparticles for RNA Self-packaging, Delivery and Cancer Therapy
Engineering Human PEG10-based Nanoparticles for RNA Self-packaging, Delivery and Cancer Therapy
PRJNA1468507 | ENA
ProteomicsAptamer-conjugated gold nanoparticles enable selective oligonucleotide delivery into muscle 2 stem cells to promote regeneration of dystrophic muscles
Inefficient targeting of muscle stem cells (MuSCs) represents a major bottleneck of current 27 therapeutic strategies for muscular dystrophies, as it precludes the possibility to promote 28 compensatory regeneration. Here we describe a novel delivery platform, based on gold nanoparticles, 29 that en...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-11 | PXD049295 | Pride
Gold nanoparticles Selex Proteomics Oligonucleotide Duchenne muscular dystrophy Aptamer 
ProteomicsStructuring lipid nanoparticles, DNA, and protein corona into stealth bionanoarchitectures for in vivo gene delivery
Lipid nanoparticles (LNPs) play a crucial role in addressing genetic disorders, and cancer, and combating pandemics such as COVID-19 and its variants. Yet, in contrast remarkable achievements in siRNA and mRNA delivery, the ability of LNPs to effectively encapsulate large-size DNA molecules remains ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD054751 | Pride
Protein corona Lipid nanoparticles Dna 
ProteomicsPeptide codes for organ-selective mRNA delivery
Organ-selective delivery of messenger RNA (mRNA) is critical for fulfilling the therapeutic potential of mRNA-based gene and protein replacement technologies. Despite clinical advances in hepatic delivery of mRNA using lipid nanoparticles (LNPs), strategies for extrahepatic organ-selective mRNA deli...
ORGANISM(S): Mus Musculus 
2023-07-20 | PXD043932 |
UnknownBrain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson's disease.
Not available
S-EPMC7577045 | biostudies-literature
TranscriptomicsEngineering Human PEG10-based Nanoparticles for RNA Self-packaging, Delivery and Cancer Therapy
Engineered protein-based protein nanoparticles (PBNPs) were developed for RNA self-packaging and delivery. To characterize the RNA cargo composition preferentially encapsulated within PEG10 PBNPs, RNA sequencing was performed on purified nanoparticle samples and producer cells. This dataset provides...
ORGANISM(S): Homo sapiens 
2026-06-13 | GSE331505 | GEO
GenomicsSpecies-dependent in vivo mRNA delivery and cellular response to nanoparticles
Species-dependent in vivo mRNA delivery and cellular response to nanoparticles
PRJNA738471 | ENA
TranscriptomicsInvestigation of Alterations in Gene Expression in the Retina Induced by Intravitreal Injection of gold and silicate nanoparticles
In this study, we investigated the gene expression induced by locally delivered gold and silicate nanoaprticles with the diameter of 20 and 100 nm in the retina. We injected nanoparticles into the vitreous cavity of 5-week-old male C57BL/6 mice. Au20 indicates gold nanoparticles of which diameters w...
ORGANISM(S): Mus musculus 
2013-07-31 | E-GEOD-49371 | biostudies-arrayexpress
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