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MetabolomicsBifidobacterium bifidum-derived nanoparticles attenuate alcoholic liver disease via enhanced hepatic phagocytosis and gastrointestinal homeostasis
Alcohol-associated liver disease (ALD) has limited therapeutic options due to its complex pathogenesis. This study demonstrates the ALD-protective effects of extracellular nanoparticles derived from Bifidobacterium bifidum (BNPs), focusing on the novel concept of gut microbiota-derived nanoparticles...
2025-06-19 | MTBLS12612 | MetaboLights
MetabolomicsPolystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism

Microplastics and nanoplastics are commonly found in our everyday environments. So far, microplastics and nanoplastics have been detected in various tissues and bodily fluids, including hair, sputum, digestive tissue, lungs, blood, and placental tissue. Although some studies indicate that micropl...

2026-02-05 | MTBLS13850 | MetaboLights
TranscriptomicsSilica nanoparticles effects on gene expression of A549 cells
Expansion of nanotechnology will bring many potential benefits as adversely effects on human health. Protection of the human respiratory system from exposure of volatile nanoparticles has become an emerging health concern. The understanding of the biological processes involved in the development and...
ORGANISM(S): Homo sapiens 
2014-09-08 | E-GEOD-53700 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of BEAS-2B cells exposed to low doses of Ag nanoparticles for 6 weeks
Human bronchial lung cells (BEAS-2B) were treated for 6 weeks with low doses (1 µg/mL) of Ag nanoparticles (10 nm citrate-coated). At the end of the exposure control and treated samples were submitted for DNA methylation analysis (Illumina 450k). The overall goal of this experiment was to evaluate p...
ORGANISM(S): Homo sapiens 
2018-04-30 | E-MTAB-6331 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of BEAS-2B cells treated with low doses of Ag nanoparticles for 6 weeks
Human bronchial lung cells (BEAS-2B) were treated for 6 weeks with low doses (1 µg/mL) of Ag nanoparticles (10 nm citrate coated). At the end of the exposure control and treated samples were submitted for RNA-Seq analysis (Hiseq2500). The overall goal of this experiment was to gain an in-depth under...
ORGANISM(S): Homo sapiens 
2018-04-30 | E-MTAB-6321 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiles of zebrafish embryos exposed to silver (nanoparticles, bulk and ions) using HT-SuperSAGE in a Illumina GA2 platform
Silver nanoparticles cause toxicity in exposed organisms and are an environmental health concern. The mechanisms of silver nanoparticle toxicity, however, remain unclear. We examined the effects of exposure to silver in nano-, bulk- and ionic forms on zebrafish embryos (Danio rerio) using a Next Gen...
ORGANISM(S): Danio rerio 
2013-06-17 | E-GEOD-38125 | biostudies-arrayexpress
TranscriptomicsToxicogenomic responses of C. elegans to gold nanoparticles
We used Au nanoparticles (Au-NPs) as a model for studying particle specific effects of manufactured nanomaterials (MNMs) by examining the toxicogenomic responses in a model soil organism, free living nematode Caenorhabditis elegans. Global genome expression for nematodes exposed to 4-nm citrate-coat...
ORGANISM(S): Caenorhabditis elegans 
2012-04-15 | E-GEOD-32521 | biostudies-arrayexpress
ProteomicsNon-labelled proteomics expression analysis of PC-3 cells treated with transferrin conjugated gold nanoparticles
Nanoparticles-based therapeutics are being clinically translated for treating cancer. Meanwhile nanoparticles are increasingly being identified as impacting cell regulation and protein expression. Here, we sought to understand how a model of a relatively inert nanoparticle without any therapeutic ag...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039433 | Pride
Antioxidant Proteomics Tem Reactive oxygen species Nanoparticle Glutathione-thioredoxin 
TranscriptomicsChanges in Arabidopsis thaliana gene expression in response to silver nanoparticles and silver ions
The release of silver nanoparticles (SNPs) in the environment has raised concerns about their effects on living organisms, including plants. In this study, changes in gene expression in Arabidopsis thaliana exposed to SNPs and silver ions (Ag+) were analyzed using Affymetrix expression microarrays. ...
ORGANISM(S): Arabidopsis thaliana 
2014-02-12 | E-MEXP-3950 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression in C57BL/6 mice intratracheally instilled with Printex 90 carbon black nanoparticles
We investigated hepatic mRNA profiles of female mice exposed to 0.162 mg Printex 90 carbon black nanoparticles by single intra-tracheal instillation. We examined responses to this dose 1, 3 and 28 days after exposure, alongside respective controls. We show that genes part of the 3-hydroxy-3-methyl-g...
ORGANISM(S): Mus musculus 
2012-04-12 | E-GEOD-35192 | biostudies-arrayexpress
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