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ProteomicsN-terminal acetylation by NatB in Arabidopsis thaliana
N-terminal acetylation (NTA) is one of the most abundant protein modifications in eukaryotes and is catalysed in humans by seven N-acetyltransferases. In this study, we investigated the Arabidopsis thaliana NatB catalytic (NAA20) and auxiliary subunit (NAA25) and their influence on protein N-termina...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-11-21 | PXD016209 | Pride
Acetyltransferase N-acetylome N-terminal acetylation Quantitative proteomics Silpronaq Gap test 
ProteomicsNatB - N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB
Determing the substrate specificity and function of NatB using knockout with rescue and knockdown in yeast and human cells respectively.
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2012-07-20 | PRD000376 | Pride
ProteomicsSequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
Alpha-synuclein (αSyn) protein levels correlate with the risk and severity of Parkinson's disease and related neurodegenerative diseases. Lowering αSyn is being actively investigated as a therapeutic modality. Here we systematically map the regulatory network that controls endogenous αSyn using sequ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD048283 | Pride
Crispr Alpha-synuclein Natb inhibition Parkinson's disease Human neurons 
GenomicsDisruption of the Nα-acetyltransferase NatB causes sensitivity to reductive stress in Arabidopsis thaliana
Disruption of the Nα-acetyltransferase NatB causes sensitivity to reductive stress in Arabidopsis thaliana
PRJNA773404 | ENA
TranscriptomicsNatB N-terminal acetyltransferase (hNAT5) inhibition
Search for genes differently expressed when we inhibit NatB N-terminal acetyltransferase. We compare gene expression after inhibiting hNAT5 expression in Hela cells with specific siRNAs expressed with adenoviruses. Keywords: gene expression comparison
ORGANISM(S): Homo sapiens 
2008-03-12 | GSE10779 | GEO
TranscriptomicsDownregulation of N-terminal initiator methionine imprinting by NatB impacts growth and the response to osmotic stress in Arabidopsis
N-terminal acetylation (NTA) is one of the most abundant protein modifications in eukaryotes and is catalyzed in humans by seven Nα-acetyltransferases (NatA-F and NatH). Remarkably, the characterization of the plant Nat machinery and its biological relevance is still in its infancy, although NTA has...
ORGANISM(S): Arabidopsis thaliana 
2020-04-14 | GSE132978 | GEO
GenomicsDownregulation of N-terminal initiator methionine imprinting by NatB impacts growth and the response to osmotic stress in Arabidopsis
Downregulation of N-terminal initiator methionine imprinting by NatB impacts growth and the response to osmotic stress in Arabidopsis
PRJNA549616 | ENA
ProteomicsYeast Nat Nt-acetylation SWATH MS
Yeast strains (wild type, Naa10 KO and Naa20 KO, resp: wt, natA-delta and natB-delta) were profiled for full proteome analysis by SWATH MS
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-12-15 | PXD015217 | Pride
Nt-acetylation Dia Nata Natb Swath ms Yeast 
TranscriptomicsDisruption of the Nα-acetyltransferase NatB causes sensitivity to reductive stress in Arabidopsis thaliana
In Arabidopsis thaliana the evolutionary conserved N-terminal acetyltransferase (Nat) complexes NatA and NatB co-translationally acetylate 60% of the proteome. Both have recently been implicated in the regulation of plant stress responses. While NatA mediates drought tolerance, NatB is required for ...
ORGANISM(S): Arabidopsis thaliana 
2021-11-29 | GSE186324 | GEO
UnknownMolecular basis for N-terminal alpha-synuclein acetylation by human NatB.
Not available
S-EPMC7494357 | biostudies-literature
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