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MetabolomicsNavigating natural variation in herbivory-induced secondary metabolism in coyote tobacco populations using MS/MS structural analysis
Natural variation can be extremely useful in unraveling the determinants of phenotypic trait evolution but has rarely been analyzed with unbiased metabolic profiling to understand how its effects are organized at the level of biochemical pathways. Native populations of Nicotiana attenuata, a wild to...
2015-06-15 | MTBLS203 | MetaboLights
ProteomicsCovalent Target Identification and Mechanism Interrogation of Anti-Cancer Natural Products
We integrated quantitative proteomics and activity-based protein profiling (ABPP) approach to systematically elucidate the involved pathways and the covalent targets of natural products.
ORGANISM(S): Homo Sapiens 
2022-08-12 | PXD036046 |
ProteomicsDiazirine photo-immobilisation for target profiling of natural products and co-factors: pulldown data
Finding the targets of natural products is of key importance in both chemical biology and drug discovery, and deconvolution of cofactor interactomes contribute to the functional annotation of the proteome. Identifying the proteins that underlie natural compound activity in phenotypic screens help to...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-10-06 | PXD033292 | Pride
Photo-immobilisation Pulldowns Natural products profiling Natural products targets 
ProteomicsMultiplexed thiol reactivity profiling for target discovery of electrophilic natural products
Electrophilic groups, such as Michael acceptors, expoxides, are common motifs in natural products (NPs). Electrophilic NPs can act through covalent modification of cysteinyl thiols on functional proteins, and exhibit potent cytotoxicity and anti-inflammatory/cancer activities. Here we describe a new...
ORGANISM(S): Homo sapiens (Human) 
2017-10-12 | PXD007575 | Pride
Mtrp natural products chemoproteomics 
UnknownAn Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures.
Not available
S-EPMC9229839 | biostudies-literature
ProteomicsThe natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa
Natural products represent a rich source for antibiotics addressing versatile cellular targets. The deconvolution of their targets via chemical proteomics is often challenged by the introduction of large photocrosslinkers. Here we select elegaphenone, a largely uncharacterized natural product antibi...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2021-09-08 | PXD010476 | Pride
Antivirulence Chemical proteomics Antimicrobials Natural products 
UnknownTargeting and extending the eukaryotic druggable genome with natural products: cytoskeletal targets of natural products.
Not available
S-EPMC7797185 | biostudies-literature
UnknownNational Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library.
Not available
S-EPMC7171602 | biostudies-literature
UnknownInsight into coronaviruses and natural products-based approach for COVID-19 treatment
Not available
S-EPMC9294970 | biostudies-literature
UnknownInflamNat: web-based database and predictor of anti-inflammatory natural products.
Not available
S-EPMC9167499 | biostudies-literature
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