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ProteomicsThe autophagy receptor NBR1 directs the clearance of photodamaged chloroplasts
The ubiquitin-binding NBR1 autophagy receptor plays a prominent role in recognizing ubiquitylated protein aggregates for vacuolar degradation during macroautophagy. Here, we show that upon exposing Arabidopsis plants to intense light, NBR1 associates with photodamaged chloroplasts independently of A...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-01-16 | PXD039183 | Pride
Microautophagy Ubiquitin. Nbr1 Chlorophagy 
ProteomicsSelective autophagy cargo receptor NBR1 is involved in plant response to sulfur deficit
Autophagy involvement in plant response to nitrogen, carbon and sulfur starvation was already reported, however the mechanisms responsible for its regulation and selectivity in such conditions were not yet investigated. We observed increased amounts of NBR1 transcript in plants exposed to sulfur def...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-05-26 | PXD016026 | Pride
Nbr1 Arabidopsis 
ProteomicsSelective autophagy regulates heat stress memory by NBR1-mediated targeting of HSP90 and ROF1
In nature, plants are constantly exposed to many transient, but recurring, stresses. Thus, to complete their life cycles they require a dynamic balance between capacities to recover following cessation of stress and maintenance of stress memory. Recently, we uncovered a new functional role of autoph...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-15 | PXD015027 | Pride
Lc-ms Autophagy Heat stress memory 
ProteomicsIdentification of NBR1 Interacting Proteins
Autophagy deficiency in breast cancer promotes metastasis through the accumulation of the autophagy cargo receptor NBR1. Here we performed tandem mass-tagged mass spectrometry analysis of immunoprecipitated NBR1 from HEK293T cell to identify proteins that interact with NBR1.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD047557 | Pride
Breast cancer Autophagy Metastasis 
GenomicsAutophagic turnover of NBR1 restricts metastatic colonization during mammary tumor progression
Autophagic turnover of NBR1 restricts metastatic colonization during mammary tumor progression
PRJNA510992 | ENA
UnknownNBR1: The archetypal selective autophagy receptor.
Not available
S-EPMC9582228 | biostudies-literature
TranscriptomicsAutophagic turnover of NBR1 restricts metastatic colonization during mammary tumor progression
Autophagy is implicated in promoting the metastatic potential of tumor cells. Utilizing a mouse model of mammary cancer to temporally delete essential autophagy regulators, ATG12 or ATG5, in tumor cells during distinct stages of carcinoma progression, we determine a stage-specific role for autophagy...
ORGANISM(S): Mus musculus 
2020-02-19 | GSE124209 | GEO
TranscriptomicsOpposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma [Quantseq]
Hepatocellular carcinoma (HCC) emerges from chronic inflammation to which activation of hepatic stellate cells (HSCs) contributes by shaping a pro-tumorigenic microenvironment. Key to this process is p62, whose inactivation leads to enhanced hepatocarcinogenesis. Here, we show that while p62 positiv...
ORGANISM(S): Mus musculus 
2024-10-22 | GSE254277 | GEO
TranscriptomicsOpposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma [RNAseq]
Hepatocellular carcinoma (HCC) emerges from chronic inflammation to which activation of hepatic stellate cells (HSCs) contributes by shaping a pro-tumorigenic microenvironment. Key to this process is p62, whose inactivation leads to enhanced hepatocarcinogenesis. Here, we show that while p62 positiv...
ORGANISM(S): Mus musculus 
2024-10-22 | GSE254276 | GEO
GenomicsOpposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma [RNAseq]
Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma [RNAseq]
PRJNA1069376 | ENA
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