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ProteomicsInterfering VE-cadherin Y685 Phosphorylation inhibits development of experimental diabetic and prediabetic retinopathy
Diabetic retinopathy involves early retinal vascular barrier breakdown and pericyte loss, yet the initiating molecular events remain poorly defined. Vascular endothelial cadherin (VE-cadherin), a key regulator of endothelial integrity, is notably reduced in diabetic and prediabetic nucleoside diphos...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-07 | PXD072047 | Pride
Y685 Pericyte Ve-cadherin Ndpkb Endothelial cell Metabolic Diabetic retinopathy 
UnknownDeficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction.
Not available
S-EPMC11846329 | biostudies-literature
TranscriptomicsPuf proteins, RNA co-immunopurification
RNA-coimmunopurifications with TAP-tagged Puf proteins from Saccharomyces cereviseae. Untagged strain (BY4741) served as a control. Cells were grown to midlog phase and harvested by centrifugation. TAP-tagged Puf proteins were affinity purified from cell-free extracts with IgG sepharose and eluted ...
ORGANISM(S): Saccharomyces cerevisiae 
2006-01-03 | E-GEOD-3968 | biostudies-arrayexpress
TranscriptomicsExtensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast
This SuperSeries is composed of the following subset Series: GSE3968: Puf proteins, RNA co-immunopurification GSE3969: Puf3delta vs. wild type comparison Abstract: Genes encoding RNA-binding proteins are diverse and abundant in eukaryotic genomes. Although some have been shown to have roles in post...
ORGANISM(S): Saccharomyces cerevisiae 
2006-03-07 | E-GEOD-4393 | biostudies-arrayexpress
TranscriptomicsCharacterization of the transcriptional roles of NME2
This SuperSeries is composed of the following subset Series: GSE18182: Expression profile of lung adenocarcinoma, A549 cells following targeted depletion of non metastatic 2 (NME2/NM23 H2) GSE18284: Genomic binding sites of non-metastatic 2 (NME2) across promoters in lung cancer A549 cells Refer to ...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-18285 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation with TAP-tagged Puf proteins from Saccharomyces cereviseae
RNA-coimmunopurifications with TAP-tagged Puf proteins from Saccharomyces cereviseae. Untagged strain (BY4741) served as a control. Cells were grown to midlog phase and harvested by centrifugation. TAP-tagged Puf proteins were affinity purified from cell-free extracts with IgG sepharose and eluted ...
ORGANISM(S): Saccharomyces cerevisiae 
2005-11-01 | E-SMDB-2622 | biostudies-arrayexpress
UnknownIdentification of Differential Protein Expression in Hepatocellular Carcinoma Induced Wistar Albino Rats by 2D Electrophoresis and MALDI-TOF-MS Analysis.
Not available
S-EPMC4820431 | biostudies-literature
TranscriptomicsExpression profile of lung adenocarcinoma, A549 cells following targeted depletion of non metastatic 2 (NME2/NM23 H2)
Non-metastatic 2 (NME2) is an established metastases suppressor in multiple human cancer types. However, the molecular mechanisms of NME2 action remain insufficiently resolved. We recently validated the transcription regulatory activity of NME2 with respect to control of proto-oncogene c-MYC express...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-18182 | biostudies-arrayexpress
TranscriptomicsExpression profile of lung adenocarcinoma, A549 cells following induction of non metastatic 2 (NME2/NM23 H2)
It is widely believed that reorganization of nucleosomes result in availability of binding sites that engage transcription factors during eukaryotic gene regulation. Recent findings, on the other hand, suggest that transcription factors induced as a result of physiological perturbations directly (or...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-40194 | biostudies-arrayexpress
TranscriptomicsGenomic binding sites of non-metastatic 2 (NME2) across promoters in lung cancer A549 cells
Non-metastatic 2 (NME2) is one of the first discovered suppressors of metastases. However, the molecular mechanisms underlying its anti-metatsic activity remain insufficiently characterized. We hypothesized that large scale transcriptional potential of NME2 might be at the core of this function. Usi...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-18284 | biostudies-arrayexpress
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