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TranscriptomicsTranscription profiling of mouse VE-cadherin null cell line vs contrik
In order to identify genes regulated by VE-cadherin expression, we compared a mouse VE-cadherin null cell line (VEC null) with the same line reconstituted with VE-cadherin wild type cDNA (VEC positive). The morphological and functional properties of these cell lines were described previously [Lampug...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-11674 | biostudies-arrayexpress
ProteomicsProximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion.
In this study, we are the first to use the MiniTurboID generation of the proximity-dependent biotin identification (BioID) technology to illuminate how the lymphatic endothelial cell (LEC) VE-cadherin interactome changes during junctional remodeling in response to the lymphangiocrine factor adrenome...
ORGANISM(S): Homo sapiens (Human) 
2024-09-05 | PXD040452 | Pride
Ve-cadherin Exocyst Lymphatic endothelial cells Adherens junctions Reelin Bioid 
GenomicsBulk RNA sequencing of VE-Cadherin+GFP+, VE-Cadherin- GFP+ and VE-Cadherin+GFP- populations from E11.5 miR144/451+/GFP mouse yolk sac.
Bulk RNA sequencing of VE-Cadherin+GFP+, VE-Cadherin- GFP+ and VE-Cadherin+GFP- populations from E11.5 miR144/451+/GFP mouse yolk sac.
PRJNA451028 | ENA
ProteomicsVE-cadherin interaction proteomics identifies ARVCF as a key stabilizer of endothelial adherens junctions
The endothelial cells lining the vascular wall maintain a selective barrier between blood and tissue. Structural connections between these endothelial cells are formed through vascular endothelial (VE)-cadherin-based adherens junctions. The extracellular domain of VE-cadherin forms homotypic bonds b...
ORGANISM(S): Homo sapiens (Human) 
2026-03-18 | PXD068012 | Pride
Ve-cadherin interaction proteomics identifies arvcf as a key stabilizer of endothelial adherens junctions 
ProteomicsInterfering VE-cadherin Y685 Phosphorylation inhibits development of experimental diabetic and prediabetic retinopathy
Diabetic retinopathy involves early retinal vascular barrier breakdown and pericyte loss, yet the initiating molecular events remain poorly defined. Vascular endothelial cadherin (VE-cadherin), a key regulator of endothelial integrity, is notably reduced in diabetic and prediabetic nucleoside diphos...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-07 | PXD072047 | Pride
Y685 Pericyte Ve-cadherin Ndpkb Endothelial cell Metabolic Diabetic retinopathy 
GenomicsSoluble VE-cadherin disrupts endothelial barrier function via VE-PTP/RhoA signalling
Soluble VE-cadherin disrupts endothelial barrier function via VE-PTP/RhoA signalling
PRJNA865806 | ENA
TranscriptomicsBulk RNA sequencing of endothelial-derived and non-endothelial-derived BMSCs and OLCs of VE-Cadherin-Cre;LoxP-tdTomato mice
We performed lineage tracing experiments using VE-Cadherin-Cre;LoxP-tdTomato mice. In these mice, endothelial cells (ECs) and their progeny are permanently marked by tdTomato fluorescence. We found that a substantial subset of stromal cells is derived from ECs, as indicated by their tdTomato express...
ORGANISM(S): Mus musculus 
2021-01-25 | E-MTAB-10020 | biostudies-arrayexpress
ProteomicsVE-cadherin associated proteins in the absence of lncRNA LASSIE
The shear stress-regulated lncRNA LASSIE interacts with junctional proteins (e.g. PECAM-1, which interacts with VE-cadherin) and influences endothelial barrier function. Here we characterize the remodeling of the VE-Cadherin complex by the lncRNA LASSIE. LASSIE silenced HUVECs were subjected to co-i...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018725 | Pride
Rna/protein interaction 
TranscriptomicsSingle-cell RNA sequencing of VE-Cadherin+ cells isolated from mouse E10.5 aorta-gonad-mesonephros region.
The aim of this experiment was to investigate cellular heterogeneity of VE-Cadherin+ cells isolated from mouse E10.5 aorta-gonad-mesonephros region.
ORGANISM(S): Mus musculus 
2019-03-12 | E-MTAB-6987 | biostudies-arrayexpress
GenomicsVE-cadherin is essential for trophoblast migration and endovascular invasion
VE-cadherin is essential for trophoblast migration and endovascular invasion
PRJNA782961 | ENA
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