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ProteomicsStoichiometric organisation of necrosome
The necrosome is a key macromolecular platform that initiates the RIPK1/RIPK3-dependent programme of cell death, termed necroptosis. Necroptosis plays an important role in controlling inflammation and cell death in multicellular organisms. Here, we used quantitative mass spectrometry to decipher the...
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD059873 | Pride
Stoichiometry Necrosome Aqua 
ProteomicsProteomic analysis of TRAIL-induced endogenous RIPK3-dependent necrosome complex
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a well-known inducer of apoptosis via formation of the primary death-inducing signaling complex (TRAIL-DISC) at the level of membrane death receptors (DR4 and DR5) which recruit successively FADD and caspase-8. TRAIL can also induce ...
ORGANISM(S): Colon Homo sapiens (Human) 
2021-03-18 | PXD003383 | Pride
Ripk3-dependent necrosome  disc  mass spectrometry  trail  trim21 
UnknownReconstitution of Human Necrosome Interactions in Saccharomyces cerevisiae.
Not available
S-EPMC7911209 | biostudies-literature
UnknownCellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination.
Not available
S-EPMC4669837 | biostudies-literature
UnknownOligomerised RIPK1 is the main core component of the CD95 necrosome.
Not available
S-EPMC12130296 | biostudies-literature
UnknownNuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis.
Not available
S-EPMC6123744 | biostudies-literature
UnknownTRIM21, a New Component of the TRAIL-Induced Endogenous Necrosome Complex.
Not available
S-EPMC8082149 | biostudies-literature
UnknownFractalkine Is Linked to the Necrosome Pathway in Acute Pulmonary Inflammation.
Not available
S-EPMC8006293 | biostudies-literature
UnknownTriad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis.
Not available
S-EPMC5964080 | biostudies-literature
UnknownObatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes.
Not available
S-EPMC3741498 | biostudies-literature
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