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ProteomicsIdentification and characterization of DNA sequences that restrict genomic binding of the glucocorticoid receptor
The glucocorticoid receptor (GR), is a hormone-activated transcription factor which binds to GR binding sequences (GBS) encoded in the genome. Interestingly, of the many genomic sequences matching the GR consensus sequence only a small subset is actually bound. This indicates that the presence of a...
ORGANISM(S): Homo sapiens (Human) 
2016-03-30 | PXD002252 | Pride
Glucocorticoid receptor Negative regulatory sequences Dna binding 
TranscriptomicsAlu sequences in undifferentiated human embryonic stem cells display high levels of A-to-I RNA editing
Adenosine to Inosine (A-to-I) RNA editing is a site-specific modification of RNA transcripts, catalyzed by members of the ADAR (Adenosine Deaminase Acting on RNA) protein family. RNA editing occurs in human RNA in thousands of different sites. Some of the sites are located in protein-coding regions ...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-19719 | biostudies-arrayexpress
GenomicsStretch-Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells
T Cell stretch-enhancers are vulnerable to Jak inhibitor tofacitinib Treatment of T cells with the Janus kinase (JAK) inhibitor, tofacitinib, disproportionately altered the expression of RA risk genes with stretech-enhancer (SE) structures.
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-60482 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cells and primordial germ cells to identify genes up-regulated in pluripotent cells
Understanding the transcriptional regulation of pluripotent cells is of fundamental interest and will greatly inform efforts aimed at directing differentiation of embryonic stem (ES) cells or reprogramming somatic cells. We first analyzed the transcriptional profiles of mouse ES cells and primordial...
ORGANISM(S): Mus musculus 
2007-07-28 | E-MEXP-1158 | biostudies-arrayexpress
UnknownThe impact of different negative training data on regulatory sequence predictions.
Not available
S-EPMC7707526 | biostudies-literature
GenomicsOX40 regulates double-negative regulatory T cells dependently of its effects on conversion and function
OX40 regulates double-negative regulatory T cells dependently of its effects on conversion and function
PRJNA421906 | ENA
UnknownIdentification of DVA interneuron regulatory sequences in Caenorhabditis elegans.
Not available
S-EPMC3557239 | biostudies-literature
UnknownRealistic artificial DNA sequences as negative controls for computational genomics.
Not available
S-EPMC4081056 | biostudies-literature
TranscriptomicsPtr-miR397a is a negative regulator of laccase genes affecting lignin content in Populus trichocarpa
Laccases were proposed to catalyze the oxidative polymerization of monolignols. We identified 49 laccase gene models in Populus trichocarpa, of which 29 were predicted to be targets of ptr-miR397a. We overexpressed Ptr-MIR397a in transgenic P. trichocarpa. In each of all 9 transgenic lines tested, 1...
ORGANISM(S): Populus trichocarpa 
2014-01-17 | E-GEOD-54153 | biostudies-arrayexpress
UnknownPleiotropy constrains the evolution of protein but not regulatory sequences in a transcription regulatory network influencing complex social behaviors.
Not available
S-EPMC4275039 | biostudies-literature
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