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ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Homo sapiens (Human) 
2026-08-29 | PXD044978 | Pride
Protein degradation Cereblon Evolution Mg-pace Zinc finger Molecular glues 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD044940 | Pride
Phage Cereblon Evolution Molecular glue Mg-pace Protein degradation 
Proteomics,MultiomicsProteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy
Muscle atrophy is a physiological response to disuse and malnutrition, but hibernating bears are largely resistant to this phenomenon. Unlike other mammals, they efficiently reabsorb amino acids from urine, periodically activate muscle contraction, and their adipocytes differentially responds to ins...
ORGANISM(S): Ursus Arctos Horribilis (ncbitaxon:116960) 
2020-01-06 | MSV000084760 | MassIVE
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Not available
S-EPMC10681943 | biostudies-literature
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S-EPMC7302988 | biostudies-literature
UnknownSociodemographic, Clinical, and Psychosocial Predictors of Short- and Long-term Study Retention in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS).
Not available
S-EPMC12451849 | biostudies-literature
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