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GenomicsThe AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD
PRJNA1124124 | ENA
TranscriptomicsReversal of persistent wound-induced retinal pigmented epithelial-to-mesenchymal transition by the TGFb pathway inhibitor, A-83-01.
Age-related macular degeneration (AMD) is a leading cause of blindness. Most vision loss occurs following the transition from a disease of deposit formation and inflammation to a disease of neovascular fibrosis and/or cell death. Here, we investigate how repeated wound stimulus leads to seminal chan...
ORGANISM(S): Homo sapiens 
2015-07-06 | E-GEOD-67898 | biostudies-arrayexpress
UnknownAqueous Fluid Transcriptome Profiling Differentiates Between Non-Neovascular and Neovascular AMD.
Not available
S-EPMC10365141 | biostudies-literature
TranscriptomicsThe AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD
Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease with degeneration of the aging retinal-pigmented epithelium (RPE) as a central pathogenic driver. Lysosomes play a crucial role in RPE health due to their involvement in phagocytosis and autophagy, which are r...
ORGANISM(S): Mus musculus 
2024-06-14 | GSE269923 | GEO
GenomicGenomic Architecture of Progression and Treatment Response in AMD

Numerous studies have identified common and rare genetic variation associated with risk of advanced age-related macular degeneration (AMD). However, risk is just one facet of AMD disease architecture. Both disease progression and response to treatment are two critical elements that may also be in...

phs001046 | dbGaP
UnknownRegulation of signaling events involved in the pathophysiology of neovascular AMD.
Not available
S-EPMC4789180 | biostudies-literature
UnknownThree-Dimensional Choroidal Vessel Analysis in Asymmetric Bilateral Age-Related Macular Degeneration: A Comparison of Active Neovascular AMD and Dry AMD Fellow Eyes.
Not available
S-EPMC12312765 | biostudies-literature
UnknownMechanisms of FH Protection Against Neovascular AMD.
Not available
S-EPMC7146894 | biostudies-literature
UnknownGenotypes of SNPs of key genes regulate susceptibility and drug sensitivity to neovascular AMD in the human population.
Not available
S-EPMC11997823 | biostudies-literature
OtherMonocyte-derived pro-angiogenic ocular macrophages localize to neovascular membranes and promote angiogenesis across species
We performed a xenium spatial transcriptomics experiment on 6 human donor maculas, 3 with neovascular AMD (consisting of 4 total tissue sections), and 3 without neovascular AMD. Data were loaded into Seurat and cells were classified according to label transfer from previous single-cell RNA sequencin...
ORGANISM(S): Homo sapiens 
2026-10-02 | GSE318037 | GEO
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