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ProteomicsPolypropylene mesh implantation for hernia repair triggers myeloid cell-dependent persistent inflammatory foreign body reaction
Polypropylene meshes that are commonly used for surgical groin hernia repair may trigger granulomatous foreign body reactions. Here, we show that asymptomatic patients display mesh-associated inflammatory granulomas long after surgery, which are dominated by monocyte-derived macrophages. In mice, su...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-24 | PXD009944 | Pride
Mouse Inflammation Chemokine Granuloma Macrophages Monocytes Biomaterial 
UnknownRate, spectrum, and evolutionary dynamics of spontaneous epimutations.
Not available
S-EPMC4450394 | biostudies-literature
MetabolomicsPseudomonas sp. Strain 273 Incorporates Organofluorine into the Lipid Bilayer during Growth with Fluorinated Alkanes
Anthropogenic organofluorine compounds are recalcitrant, globally distributed, and a human health concern. Although rare, natural processes synthesize fluorinated compounds, and some bacteria have evolved mechanisms to metabolize organofluorine compounds. Pseudomonas sp. strain 273 grows with...
2022-06-06 | MTBLS3893 | MetaboLights
UnknownScreen-detected atrial fibrillation predicts mortality in elderly subjects.
Not available
S-EPMC7842093 | biostudies-literature
UnknownPolypropylene mesh implantation for hernia repair causes myeloid cell-driven persistent inflammation.
Not available
S-EPMC6413778 | biostudies-literature
UnknownPresence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition.
Not available
S-EPMC9393725 | biostudies-literature
UnknownIonizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII.
Not available
S-EPMC3898380 | biostudies-literature
UnknownGFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemia.
Not available
S-EPMC9417998 | biostudies-literature
TranscriptomicsGene expression profiling of mouse experimental autoimmune encephalomyelitis (EAE) from spinal cord preparations of opticospinal EAE (OSE) and MOG-induced EAE
Genetic opticospinal EAE (OSE) and MOG-induced EAE (MOG-EAE) are two experimental autoimmune encephalomyelitis (EAE) mouse models of human multiple sclerosis. For the OSE model, double-transgenic 2D2 (TCRMOG) x IgHMOG mice were used. For MOG-EAE, wildtype C57BL/6 mice were immunized with a MOG pept...
ORGANISM(S): Mus musculus 
2020-08-21 | E-MTAB-9132 | biostudies-arrayexpress
MetabolomicsInhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

BACKGROUND: Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall survival rate of high-risk disease remai...

2022-11-30 | MTBLS858 | MetaboLights
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