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TranscriptomicsImmunomagnetic purification of mES derived neuronal precursors increases neuronal migration and differentiation in vivo
All established protocols for differentiation of mouse and human pluripotent stem cells into specific neural subpopulations generate a considerable cellular heterogeneity that hampers experimental and clinical progress. In order to obtain a homogenous population of neuronal precursor cells and to st...
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-35125 | biostudies-arrayexpress
TranscriptomicsTranscriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment
Human brain development is a complex process involving neural proliferation, differentiation, and migration which are directed by many essential cellular factors and drivers. Here, using the NetBID2 algorithm and developing human brain RNA sequencing(RNA-Seq) dataset, we identified synaptotagmin-lik...
ORGANISM(S): Homo sapiens 
2021-02-07 | E-MTAB-10058 | biostudies-arrayexpress
TranscriptomicsDNA methylation, H3K4me2, H3K27me3, Pol2 promoter profiling during neuronal differentiation
Cellular differentiation entails loss of pluripotency and parallel gain of lineage-specific and ultimately cell-type specific characteristics. Using a murine system that progresses from stem cells to lineage-committed progenitors and further to terminally differentiated neurons we analyzed two repre...
ORGANISM(S): Mus musculus 
2008-06-04 | E-GEOD-11489 | biostudies-arrayexpress
TranscriptomicsPtbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain [HITS-CLIP]
Two polypyrimidine tract RNA-binding proteins (PTBs), one near-ubiquitously expressed (Ptbp1) and another highly tissue-restricted (Ptbp2), regulate RNA in interrelated but incompletely understood ways. Ptbp1, a splicing regulator, is replaced in the brain and differentiated neuronal cell lines by P...
ORGANISM(S): Mus musculus 
2013-05-31 | E-GEOD-47564 | biostudies-arrayexpress
TranscriptomicsGeminin knockdown in embryonic stem cell-derived neural precursors
Regulating the transition from lineage-restricted progenitors to terminally differentiated cells is a central aspect of nervous system development. Here, we investigated the role of the nucleoprotein Geminin in regulating neurogenesis at a mechanistic level during both Xenopus primary neurogenesis a...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-39657 | biostudies-arrayexpress
UnknownThe Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis.
Not available
S-EPMC6828949 | biostudies-literature
UnknownEffects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3.
Not available
S-EPMC6671084 | biostudies-literature
TranscriptomicsSingle Cell Analysis Reveals Unexpected Transcriptional Heterogeneity of Neural Progenitors in the Developing Human Cortex
The human cerebral cortex depends for its normal development and size on a precisely controlled balance between self-renewal and differentiation of diverse neural progenitor cells. Specialized progenitors that are common in humans, but virtually absent in rodents, called â??outer radial gliaâ?? (ORG...
ORGANISM(S): Homo sapiens 
2015-02-24 | E-GEOD-66217 | biostudies-arrayexpress
TranscriptomicsDirect Conversion of Human Fibroblasts into Neuronal Restricted Progenitors
Neuronal restricted progenitors (NRPs) represent a type of transitional intermediate cells that lie between multipotent neural progenitors (NPs) and terminal differentiated neurons during neurogenesis. These NRPs have the ability to self-renew and differentiate into neurons, but not into glial cells...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-51580 | biostudies-arrayexpress
ProteomicsProteomic signatures of schizophrenia-sourced iPSC-derived neural progenitors and neurons
Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an early developmental deficiency with a more specifically neurodevelopmental origin. Understan...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD026593 | Pride
Neuron Scz Neural cell Disease Hnpc Organoid Ips Proteome 
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