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ProteomicsNeuronal ribosomes dynamically exchange ribosomal proteins in a context-dependent manner.
Owing to their morphological complexity and dense network connections, neurons modify their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue enriched for dendrites and axons). Although ribosome biogenesis largely takes place in the nucleus and perinuclear region, neuronal...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-20 | PXD026973 | Pride
Neuronal ribosomes Prm Rrna Ribosome assembly Protein complex Stress H2o2 Ribosomal proteins Protein synthesis Translation Local translation Psilac Neurons Neuronal processes Silac Ribosome Ribosome biogenesis Oxidative stress Hydrogen peroxide 
GenomicsFMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall
FMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall
PRJNA1234679 | ENA
TranscriptomicsFunctionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience
The subcellular localization and translation of messenger RNA (mRNA) supports functional differentiation between cellular compartments. In neuronal dendrites, local translation of mRNA provides a rapid and specific mechanism for synaptic plasticity and memory formation, and might be involved in the ...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-58343 | biostudies-arrayexpress
GenomicsGTPBP1 resolves paused ribosomes to maintain neuronal homeostasis
GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis
PRJNA663319 | ENA
UnknownPuromycin reveals a distinct conformation of neuronal ribosomes.
Not available
S-EPMC10873636 | biostudies-literature
TranscriptomicsFMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall
Local protein synthesis is a crucial process that maintains synaptic proteostasis. Ribosomes stalled at elongation make up a sizable percentage of mRNAs translated in developing neurons. The protein lost in Fragile X syndrome (FMRP) is highly enriched in RNA granules containing stalled ribosomes, bo...
ORGANISM(S): Mus musculus 
2026-06-18 | GSE291701 | GEO
UnknownNeuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins.
Not available
S-EPMC8531293 | biostudies-literature
UnknownGTPBP1 resolves paused ribosomes to maintain neuronal homeostasis.
Not available
S-EPMC7665888 | biostudies-literature
ProteomicsMonosomes actively translate synaptic mRNAs in neuronal processes
In order to deal with their huge volume and complex morphology, neurons localize mRNAs and ribosomes near synapses to produce proteins locally. A relative paucity of polyribosomes (considered the active sites of translation) detected in electron micrographs of neuronal processes (axons and dendrites...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-27 | PXD016552 | Pride
Neuronal processes Monosomes Mrna Protein synthesis 
TranscriptomicsGTPBP1 resolves paused ribosomes to maintain neuronal homeostasis
Ribosome-associated quality control pathways respond to defects in translational elongation to recycle arrested ribosomes and degrade aberrant polypeptides and mRNAs. Loss of an individual tRNA gene leads to ribosomal pausing that is resolved by the translational GTPase GTPBP2, and in its absence ca...
ORGANISM(S): Mus musculus 
2020-10-26 | GSE157902 | GEO
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