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UnknownImmunomodulatory Mechanisms of Rehmanniae Radix Praeparata-Achyranthes Root-Chinese Angelica Root Combination in Nontraumatic Osteonecrosis of the Femoral Head: A Comprehensive Network Pharmacology and Molecular Docking Study Focusing on Immunological Pathways.
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S-EPMC12767418 | biostudies-literature
TranscriptomicsAn RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation
Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor. The brain-infiltrative character of glioblastoma makes complete surgical removal of the tumor impossible and neither radiation nor current chemotherapy provide cure. Recent evidence shows that glioblastoma mu...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-27931 | biostudies-arrayexpress
TranscriptomicsThe NRF2-KEAP1 pathway is an early responsive gene network in arsenic exposed lymphoblastoid cells
Inorganic arsenic, a major environmental contaminant, has risen as an important health problem worldwide. More detailed identification of the molecular mechanisms associated with iAs exposure would help to establish better strategies for prevention and treatment. Although chronic iAs exposures have ...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-51454 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of rhabdomyosarcoma tumor samples
In order to identify the specific DNA methylation pattern of different rhabdomyosarcoma (RMS) samples we performed a genome-wide study using Human DNA methylation platform (Agilent). DNA methylation profiling was carried out in 15 RMS tumor samples using the Human DNA methylation microarray (Agilent...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-67201 | biostudies-arrayexpress
TranscriptomicsHigh IGFBP2 Expression Correlates with Tumor Severity in Pediatric Rhabdomyosarcoma.
Rhabdomyosarcoma (RMS) is the most common childhood sarcoma and is identified as either the embryonal or alveolar (ARMS) subtype. In approximately 75% of cases, ARMSs are characterized by specific chromosomal translocations that involve PAX and FKHR genes. ARMS gene expression signatures vary, depen...
ORGANISM(S): Homo sapiens 
2011-12-05 | E-GEOD-23196 | biostudies-arrayexpress
TranscriptomicsComparison of WAT CD34+ vs LAF CD34+
A catalytic role has been proposed in neoplastic angiogenesis and cancer progression for bone marrow-derived endothelial progenitor cells (EPCs). However, in preclinical and clinical studies the quantitative role of marrow-derived EPCs in cancer vascularization was found to be extremely variable. Ad...
ORGANISM(S): Homo sapiens 
2011-08-15 | E-GEOD-31415 | biostudies-arrayexpress
TranscriptomicsFunctional screen for novel regulators of murine hematopoietic stem cell in vivo repopulating activity
Although Hematopoietic Stem Cell Transplantation (HSCT) routinely treats hematologic disease, many patients experience adverse outcomes. Understanding the molecular regulation of HSC engraftment is paramount to improving HSCT regimens. Here, we executed a large-scale transplant-based functional sc...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-63830 | biostudies-arrayexpress
TranscriptomicsId proteins synchronize stemness and anchorage to the niche of neural stem cells
Stem cell functions require activation of stem cell-intrinsic transcriptional programs as well as intimate extracellular interactions with a niche microenvironment. How the core pluripotency transcriptional machinery controls residency of stem cells in the niche microenvironment is unknown. Here we ...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-36488 | biostudies-arrayexpress
TranscriptomicsComparison of WAT EPCs vs WAT ASCs
Human adipose tissue contains two populations of progenitors (EPCs and ASCs) with cooperative roles in breast cancer. EPCs (CD45-CD34+CD31+CD13-CCRL2+) can generate endothelial cells. ASCs (CD45-CD34+CD31-CD13+CD140b+) are mesenchymal progenitors which generated pericytes. CD13+ cells and CD13- cell...
ORGANISM(S): Homo sapiens 
2013-07-05 | E-GEOD-44302 | biostudies-arrayexpress
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