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UnknownSeven-Month Prostate-Specific Antigen Is Prognostic in Metastatic Hormone-Sensitive Prostate Cancer Treated With Androgen Deprivation With or Without Docetaxel.
Not available
S-EPMC5805480 | biostudies-literature
MetabolomicsMulti-dimensional leaf phenotypes reflect root system genotype in grafted grapevine over the growing season

BACKGROUND: Modern biological approaches generate volumes of multi-dimensional data, offering unprecedented opportunities to address biological questions previously beyond reach owing to small or subtle effects. A fundamental question in plant biology is the extent to which below...

2022-01-07 | MTBLS2831 | MetaboLights
UnknownFirst-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer.
Not available
S-EPMC5648176 | biostudies-literature
UnknownPooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria.
Not available
S-EPMC7318010 | biostudies-literature
ProteomicsSpecificity of phosphorylation responses to MAP kinase pathway inhibitors in melanoma cells, experiment 1 of 2
We used phosphoproteomics to compare the responses of the ERK1/2 inhibitors, SCH772984 and GDC0994, and the MKK1/2 inhibitor, trametinib. These are compared with responses to the MKK1/2 inhibitor, selumetinib (AZD6244), previously measured by our lab in the same metastatic melanoma cell line. In thr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007620 | Pride
Human Melanoma Silac Selumetinib Trametinib Gdc0994 Sch772984 
ProteomicsSpecificity of phosphorylation responses to MAP kinase pathway inhibitors in melanoma cells, experiment 2 of 2
We used phosphoproteomics to compare the responses of the ERK1/2 inhibitors, SCH772984 and GDC0994, and the MKK1/2 inhibitor, trametinib. These are compared with responses to the MKK1/2 inhibitor, selumetinib (AZD6244), previously measured by our lab in the same metastatic melanoma cell line. In thr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007621 | Pride
Human Melanoma Silac Selumetinib Trametinib Gdc0994 Sch772984 
UnknownPiperaquine Pharmacokinetics during Intermittent Preventive Treatment for Malaria in Pregnancy.
Not available
S-EPMC8092554 | biostudies-literature
TranscriptomicsTranscription profiling of yeast expressing wild type C. albicans G33 ser-tRNACAG and the mutant T33 ser-tRNACAG which trigger genetic code ambiguity
S. cerevisiae expressing the wild-type C. albicans G33 ser-tRNACAG and the mutant T33 ser-tRNACAG that trigger genetic code ambiguity were compared against control yeast using two-color oligo arrays
ORGANISM(S): Saccharomyces cerevisiae 
2007-11-08 | E-TABM-196 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA copy number predictors of lapatinib sensitivity in tumour-derived cell lines
A common aim of pharmacogenomic studies that employ genome-wide assays on panels of cancers is the unbiased discovery of genomic alterations that are associated with clinical outcome and drug response. Previous investigations of lapatinib, a selective dual-kinase inhibitor of EGFR and HER2 tyrosine...
ORGANISM(S): Homo sapiens 
2008-03-10 | E-GEOD-9585 | biostudies-arrayexpress
TranscriptomicsA comparison of DNA copy number profiling platforms using a panel of melanoma cell lines
The accurate mapping of recurring DNA copy number aberrations (CNAs), a hallmark feature of the cancer genome, has facilitated the discovery of tumor suppressor genes and oncogenes. Microarray-based assays designed to detect these chromosomal copy number alterations on a genome-wide and high-resolu...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-7822 | biostudies-arrayexpress
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