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TranscriptomicsS-adenosylmethionine modifies cocaine-induced DNA methylation and increases locomotor sensitization in mice
The aim of the study was to investigate whether environmental factors like S-adenosylmethionine (SAM) via affecting epigenome could alter cocaine-induced gene expression and locomotor sensitization in mice. Using mouse nucleus accumbens (NAc) tissue, whole-genome gene expression profiling revealed t...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48365 | biostudies-arrayexpress
ProteomicsA SAM key domain required for enzymatic activity and allosteric activation of the Fun30 nucleosome remodeler
Fun30 is the prototype of the Fun30-SMARCAD1-ETL sub-family of nucleosome remodelers involved in DNA repair and gene silencing. These proteins appear to act as single subunit nucleosome remodelers, but their molecular mechanisms are, at this point, poorly understood. Using multiple sequence alignmen...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-07-18 | PXD037249 | Pride
Sam Fun30 Yeast Chromatin Resection Regulation Key 
TranscriptomicsEvaluation of a New High-Dimensional miRNA Profiling Platform
We evaluated a new miRNA profiling platform that utilizes Illumina’s existing robust DASL chemistry as the basis for the assay. Using total RNA from five colon cancer patients and four cell lines, we evaluated the reproducibility of miRNA expression levels across replicates and with varying amoun...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-17346 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of mouse whole genome using self-amplifying messenger (SAM) RNA delivered with different formulations compared to controls
RNA-baffsed vaccines have recently emerged as a promising alternative to the use of DNA-based and viral vector vaccines, in part due to the potential to simplify how vaccines are made and facilitate a rapid response to newly emerging infections. SAM vaccines are based on engineered self-amplifying m...
ORGANISM(S): Mus musculus 
2017-04-30 | E-MTAB-5603 | biostudies-arrayexpress
GenomicsSAM treatment of CRC cell lines
SAM treatment of CRC cell lines
PRJNA640675 | ENA
TranscriptomicsTranscription profiling of murine neurons in the nodose and dorsal root ganglia to elucidate molecular characteristics of different sensory neorons.
Vagal afferent neurons are thought to convey primarily physiological information, whereas spinal afferents transmit noxious signals from the viscera to the central nervous system. In order to elucidate molecular identities for these different properties, we compared gene expression profiles of neu...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2917 | biostudies-arrayexpress
GenomicsNNMT overexpression promotes tubular senescence and fibrosis in human chronic kidney disease (NAM and SAM supplementation in TEC cells) [Series_2]
NNMT overexpression promotes tubular senescence and fibrosis in human chronic kidney disease (NAM and SAM supplementation in TEC cells) [Series_2]
PRJNA1179387 | ENA
GenomicsNNMT overexpression promotes tubular senescence and fibrosis in human chronic kidney disease (NNMT inhibition and SAM supplementation in TEC cells)
NNMT overexpression promotes tubular senescence and fibrosis in human chronic kidney disease (NNMT inhibition and SAM supplementation in TEC cells)
PRJNA1366970 | ENA
TranscriptomicsExpression profiling of HeLa cells at S and G2/M phases of mitotic cell cycle.
We compared the mRNAs expression profile of HeLa cells between two phases of the mitotic cell cycle: S and G2/M phases. Results provide insight into the regulation of transcript levels during mitotic cell cycle progression. HeLa cells were synchronized with double thymidine blockade (12 hours with ...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-15547 | biostudies-arrayexpress
ProteomicsMethyl-SILAF mapping of the Drosophila mitochondrial protein methylome
S-adenosylmethionine (SAM) is the principal biological methyl group donor for a diverse range of substrates. It is synthesised in the cytosolic methionine cycle and shuttled throughout the cell. The mitochondrial SAM (mitoSAM) pool depends on import through the inner-membrane S-adenosylmethionine ca...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-02-21 | PXD019654 | Pride
Ptm Mitochondria Methylation Drosophila 
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