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ProteomicsHLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis
Autoimmune diseases are often associated with HLA molecules. Multiple sclerosis (MS) is a prototypical example with the HLA-DR15 haplotype as strongest genetic factor. How it contributes to MS is not clear, but key to understand this and other autoimmune diseases. Autoreactive CD4+ T cells and proin...
ORGANISM(S): Homo sapiens (Human) 
2020-10-22 | PXD015249 | Pride
Multiple sclerosis Hla cross-restriction Immunopeptidome B cells Hla-dr-derived self-peptides Cross-reactivity Hla-dr15 molecules Autoreactive cd4+ t cells 
UnknownHLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis.
Not available
S-EPMC7707104 | biostudies-literature
UnknownIL-7-dependent and -independent lineages of IL-7R-dependent human T cells.
Not available
S-EPMC11444196 | biostudies-literature
UnknownResident Performance on the Fundamentals of Arthroscopic Surgery Training (FAST) Workstation Does Not Predictably Improve With Postgraduate Year.
Not available
S-EPMC10840096 | biostudies-literature
UnknownImmune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations.
Not available
S-EPMC10132165 | biostudies-literature
UnknownDiscovery of an allosteric site in the caspases.
Not available
S-EPMC514654 | biostudies-literature
UnknownHLA-B*15:01-positive severe COVID-19 patients lack CD8<sup>+</sup> T cell pools with highly expanded public clonotypes.
Not available
S-EPMC12435269 | biostudies-literature
ProteomicsUBE2O remodels the proteome during terminal erythroid differentiation
Terminal differentiation is characterized by a respecification of the global protein complement, as epitomized by erythrocytes, whose cytosol is ~98% globin. Remodeling of the proteome involves programmed elimination of generic cellular constituents in parallel with synthesis of cell-type-specific p...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-08-08 | PXD005904 | Pride
Red blood cell Proteomics Ms3 Tmt Ube2o Proteasome Ubiquitin 
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
UnknownAntibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma.
Not available
S-EPMC7821912 | biostudies-literature
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