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Proteomics (2)
Unknown (1)

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Acidithiobacillus ferrooxidans ATCC 53993 (2)
Aerococcus urinae NBRC 15544 = CCUG 36881 (2)
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Arabidopsis thaliana (2)
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Repository

pride (2)

Tissue

B cell (2)
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Cell culture (1)
Primary cell (1)

Disease

Acute leukemia (2)

Technology Type

Affinity purification coupled with mass spectrometry proteomics (2)
Mass Spectrometry (2)
Shotgun proteomics (2)

Publication Date

2022 (1)
2020 (1)

Release Date

2021 (1)

Lab affiliation

Department of Laboratory Medicine, UCSF (1)
UCSF Department of Laboratory Medicine (1)

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Surface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in refractory B-cell malignancies

Alternate strategies are needed for B-cell malignancy patients relapsing after CD19-targeted immunotherapy. Here, integrated cell surface proteomics and epigenetic analysis initially revealed CD72 as an optimal target for poor-prognosis MLL-rearranged B-ALL, which we further found to be expressed wi...

ORGANISM(S): Homo sapiens (Human)

2022-02-15 | PXD016800 | Pride

IFITM3-mediated regulation of cell membrane dynamics is essential for malignant B-cell transformation

B cell receptor (BCR) signaling and oncogenic tyrosine kinases that mimic BCR-signaling in B-lineage leukemia and lymphoma depend on assembly of membrane proximal signaling complexes. Signalosomes in normal BCR- and oncogene (e.g. BCR-ABL1, RAS-pathway lesions) signal transduction are recruited to p...

ORGANISM(S): Mus musculus (Mouse)

2020-12-18 | PXD014691 | Pride

Leukemia Bcr signaling Cell surface Lipid rafts

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

Not available

S-EPMC7884931 | biostudies-literature

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