Sort   by:  
 Page size 
GenomicsNMT inhibition in the context of MYC levels
NMT inhibition in the context of MYC levels
PRJNA645908 | ENA
ProteomicsN-Myristoyltransferase inhibition in HeLa
N-Myristoyltransferase (NMT) covalently attaches a C14-fatty acid to the N-terminal glycine of proteins and has been proposed as a therapeutic target in cancer. We used quantitative proteomics to map protein expression changes for more than 2700 proteins in response to treatment with an NMT inhibito...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080783 | MassIVE
TranscriptomicsNMT inhibition in the context of MYC levels
Characterisation of the impact of 24 hours of NMT inhibition (100 nM IMP1088) on the P493-6 cell line with medium levels of MYC and high levels of MYC.
ORGANISM(S): Homo sapiens 
2022-06-30 | GSE154336 | GEO
GenomicsEffect of NMT inhibition on a model of NALFD in mice
Effect of NMT inhibition on a model of NALFD in mice
PRJNA929512 | ENA
ProteomicsProfiling N-myristoyltransferase activity and inhibition in breast cancer cells (MD-MB-231) using Sortase-A labelling
We report a novel application for Sortase A (SrtA), labeling N-terminal Gly proteins across the proteome at endogenous levels. We combined SrtA labeling of whole-cell lysates with a potent and selective NMT inhibitor, delivering a method capable of quantifying changes in cellular NMT activity in mul...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD010634 | Pride
Sortase a  srta  n-myristoylation  nmt 
ProteomicsN-Myristoyltransferase inhibition in HeLa
N-Myristoyltransferase (NMT) covalently attaches a C14-fatty acid to the N-terminal glycine of proteins and has been proposed as a therapeutic target in cancer. We used quantitative proteomics to map protein expression changes for more than 2700 proteins in response to treatment with an NMT inhibito...
ORGANISM(S): Homo sapiens (Human) 
2016-06-13 | PXD003186 | Pride
Hela N-myristoyltransferase inhibition Q-exactive Spike-in silac 
TranscriptomicsEffect of NMT inhibition on a model of NALFD in mice
To examine the effects of NMTi treatment on progression of NAFLD model, mice on chow or high-fat diet were treated with vehicle or additionally on high-fat diet treated with DDD86481. Transcriptional analysis was performed after 19 weeks of high-fat diet with monthly treatments with 3 rounds of NMT ...
ORGANISM(S): Mus musculus 
2023-09-28 | GSE224069 | GEO
ProteomicsLabel-free quantification of NMT1 and NMT2 knockout as well as PCLX-001 treated HAP1 cells
HAP1 cells with an NMT1, NMT2, or double knockout (as well as wildtype controls) were prepared by in-gel trypsin digestion and analyzed by LC-MS/MS label-free quantification (data-dependent acquisition). Additionally, HAP1 cells were treated with PCLX-001, an NMT inhibitor, at EC50 and EC90 (as well...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-05-10 | MSV000091913 | MassIVE
ProteomicsGlobal profiling of myristoylation in Toxoplasma gondii
N-myristoylation is a ubiquitous class of protein lipidation across eukaryotes and N-myristoyl transferase (NMT) has been proposed as an attractive drug target in several pathogens. Here we describe the first global chemoproteomic analysis of protein myristoylation in Toxoplasma gondii. Through quan...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2020-07-06 | PXD019677 | Pride
N-myristoylation Chemical proteomics Toxoplasma Nmt inhibition 
ProteomicsInhibition of protein N-myristoylation blocks Plasmodium falciparum intracellular development and egress, but myristoylation of GAP45 is required only for erythrocyte invasion.
In this project, the aim was to investigate the effect of NMT inhibition during schizogony, synchronized parasite populations.
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-10-07 | PXD022704 | Pride
Lc-ms/ms N-myristoylation Plasmodium faciparum 
Sort   by:  
 Page size