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ProteomicsHigh-dose oncogenic PIK3CA drives constitutive cellular stemness through increased NODAL/TGFb signaling
Oncogenic PIK3CA mutations activate phosphoinositide 3-kinase (PI3K) and are among the commonest somatic mutations in cancer and mosaic, developmental overgrowth disorders. We recently demonstrated that the ‘hotspot’ variant PIK3CAH1047R exerts striking allele dose-dependent effects on stemness in h...
ORGANISM(S): Homo sapiens (Human) 
2021-03-03 | PXD014719 | Pride
Proteomics Tfgb Nodal ipsc Cancer Transcriptomics Pik3ca 
UnknownModulation of WNT, Activin/Nodal, and MAPK Signaling Pathways Increases Arterial Hemogenic Endothelium and Hematopoietic Stem/Progenitor Cell Formation During Human iPSC Differentiation.
Not available
S-EPMC10346406 | biostudies-literature
TranscriptomicsDifferent propensity in hematopoietic differentiation potential among distinct human pluripotent stem cell lines
Lineage-specific differentiation potential varies among different human pluripotent stem cell (hPSC) lines. A stem cell bank may advice researchers on which hPSCs exhibit the highest differentiation potential for a certain lineage. In this study, we aimed at characterizing the hematopoietic differen...
ORGANISM(S): Homo sapiens 
2010-07-24 | E-GEOD-23091 | biostudies-arrayexpress
TranscriptomicsCell Fusion Enhances Mesendodermal Differentiation of Human Induced Pluripotent Stem Cells.
Human induced pluripotent stem cells (iPS cells) resemble embryonic stem cells and can differentiate into cell derivatives of all three germ layers. However, frequently the differentiation efficiency of iPS cells into some lineages is rather poor. Here, we found that fusion of iPS cells with human h...
ORGANISM(S): Homo sapiens 
2014-08-06 | E-GEOD-58457 | biostudies-arrayexpress
UnknownOptimizing the Use of iPSC-CMs for Cardiac Regeneration in Animal Models.
Not available
S-EPMC7552322 | biostudies-literature
UnknownNodal/Activin signaling predicts human pluripotent stem cell lines prone to differentiate toward the hematopoietic lineage.
Not available
S-EPMC2997587 | biostudies-literature
UnknownHapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping.
Not available
S-EPMC11010450 | biostudies-literature
UnknownAn iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions.
Not available
S-EPMC8324498 | biostudies-literature
UnknownAn improved approach to generate IL-15+/+/TGFβR2-/- iPSC-derived natural killer cells using TALEN.
Not available
S-EPMC11440057 | biostudies-literature
UnknownDevelopmental changes in electrophysiological characteristics of human-induced pluripotent stem cell-derived cardiomyocytes.
Not available
S-EPMC5421365 | biostudies-literature
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