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ProteomicsSingle cell RNA-seq analysis links respiratory dysfunction to an extracellular matrix-specific damage response
Energy metabolism and extracellular matrix function are closely connected to orchestrate and maintain tissue organization, but the crosstalk is poorly understood. Here, we used scRNA-seq analysis to uncover the importance of respiration for extracellular matrix homeostasis in mature cartilage. Genet...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027109 | Pride
Cartilage Respiration Ecm 
ProteomicsmTORC1 regulates GRASP55-dependent unconventional secretion in response to stress
In cells, several cargoes are delivered to the cell surface or the extracellular space via unconventional secretion routes. GRASP55 is a Golgi protein that regulates unconventional secretion of distinct proteins and controls the assembly and membrane stacking of Golgi cisternae. Recent work suggeste...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020331 | Pride
Grasp55 Golgi Cellular stress response Mtorc1 Tsc2 Unconventional secretion Rapamycin 
ProteomicsSkeletal muscle-specific methyltransferase METTL21C trimethylates p97 and regulates autophagy-associated protein breakdown
Protein aggregates and cytoplasmic vacuolization are major hallmarks of multisystem proteinopathies (MSP) that lead to muscle weakness. Here, we identify METTL21C as a novel skeletal muscle-specific lysine methyltransferase. Insertion of a -galactosidase cassette into the Mettl21c mouse locus reveal...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-05-04 | PXD008145 | Pride
Proteomics Methylation Proteostasis 
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