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ProteomicsCell-specific non-canonical amino acid labelling identifies changes in the hippocampal de novo proteome during memory formation
The formation of spatial long-term memory (LTM) requires the de novo synthesis of distinct sets of proteins; however, a non-biased examination of the de novo proteome in this process is lacking. Here, we generated a novel mouse strain, which enables cell-type-specific labelling of newly synthesised ...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD015820 | Pride
Long-term memory Non-canonical amino acid labelling Azidohomoalanine Azidonorleucine Swath Active place avoidance Protein synthesis Mrna splicing 
ProteomicsDecreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling
Tau is a scaffolding protein which serves multiple cellular functions that are perturbed in neurodegenerative diseases, including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). We have recently shown that amyloid-, the second hallmark of AD, induces de novo protein synthesis of tau. Imp...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-17 | PXD013341 | Pride
Tauopathy Non-canonical amino acid labelling Neurodegenerative disease. Protein synthesis Ribosomal proteins 
ProteomicsOptimization of Bio-Orthogonal Non-Canonical Amino acid Tagging (BONCAT) for effective low-disruption labelling of Arabidopsis proteins in vivo
Plants, as sessile organisms, require robust responses in protein synthesis to adapt to variable environmental conditions. Measurement of newly synthesized proteins has been successfully facilitated with Bio-Orthogonal Non-Canonical Amino acid Tagging (BONCAT) across a multitude of organisms. Here, ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-06-08 | PXD064210 | Pride
Mass spectrometry Boncat Click chemistry Quantitative proteomics 
UnknownCell-specific non-canonical amino acid labelling identifies changes in the de novo proteome during memory formation.
Not available
S-EPMC6944461 | biostudies-literature
UnknownDecreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling.
Not available
S-EPMC6600635 | biostudies-literature
UnknownA Dual-Purpose Non-Canonical Amino Acid for the Expanded Genetic Code: Combining Metal-Binding and Click Chemistry.
Not available
S-EPMC11656133 | biostudies-literature
TranscriptomicsGene expression profiles of canonical and non-canonical NF-κB signaling pathways in Hodgkin’s lymphoma
Malignant Hodgkin's lymphoma (HL) cells are characterized by constitutive activation of the canonical as well as the non-canonical NF-κB signaling cascades. We depleted subunit combinations corresponding to either canonical (p50/RelA) or non-canonical (p52/RelB) dimers in the HL cell line L-1236 an...
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-64232 | biostudies-arrayexpress
UnknownBioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome.
Not available
S-EPMC11210150 | biostudies-literature
TranscriptomicsTranscription profiling of wild type Halobacterium salinarum R1 growing with or without aromatic amino acids
Medium-adapted cultures of H. salinarum were grown in synthetic medium with or without AroAA, and cells harvested by centrifugation after growth had reached OD600nm=0.2 and 0.58, respectively.
ORGANISM(S): Halobacterium salinarum 
2014-12-01 | E-MEXP-3818 | biostudies-arrayexpress
UnknownA genetically encoded aldehyde for rapid protein labelling.
Not available
S-EPMC4062584 | biostudies-literature
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