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Proteomicsnon-canonical HLA peptides in cancer
Efforts to precisely identify tumor human leukocyte antigen presented peptides (HLAp) capable of mediating T cell based tumor rejection still face important challenges. Recent reports suggest that non-canonical cancer HLAp could be immunogenic but their identification requires highly sensitive and a...
ORGANISM(S): Homo sapiens (Human) 
2020-03-27 | PXD013649 | Pride
Non-canonical translation products Mass spectrometry Cancer immunotherapy Immunopeptidomics Antigen discovery 
ProteomicsDiscovery of Non-Canonical Peptides Derived from Novel Small Open Reading Frames as MHC-I Epitopes
Immunopeptides that are translated in cells and presented at the cell surface by major histocompatibility complex (MHC) mole-cules are important epitopes in basic Immunology and translational cancer immunotherapy. While most of the reported immuno-peptides are derived from protein coding sequence, t...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD024415 | Pride
Price Ribotish Sorf Non-canonical peptides Lc-ms Mhc-i 
ProteomicsLarge-scale discovery of non-canonical peptides in monocot and dicot plants through an integrated peptidogenomic pipelineLarge-scale discovery of non-canonical peptides in monocot and dicot plants through an integrated peptidogenomic pipeline
Non-canonical peptides (NCPs) have been shown to play critical roles in fundamental biological processes. Despite their importance, NCPs have been rarely identified and characterized in plants. Here we developed an integrated peptidogenomic pipeline using high-throughput mass spectra to probe custom...
ORGANISM(S): Zea mays (Maize) 
2020-08-11 | PXD017081 | Pride
Plants Six-frame translation Mass spectrometry Peptidogenomics Non-canonical peptides 
ProteomicsImmunopeptidomics-based identification of naturally presented non-canonical circRNA-derived peptides
Circular RNAs (circRNAs) are covalently closed non-coding RNAs lacking the 5’ cap and the poly-A tail. Nevertheless, it has been demonstrated that certain circRNAs can undergo active translation. Therefore, aberrantly expressed circRNAs in human cancers could be an unexplored source of tumor-specifi...
ORGANISM(S): Homo sapiens (Human) 
2024-03-20 | PXD043989 | Pride
Immunopeptidomics Circrna Antigen discovery 
ProteomicsA lifespan multi-tissue atlas of non-canonical peptides reveals organ- and life-stage-specific proteomic remodeling in mice
This study presents a lifespan multi-tissue proteomic atlas of non-canonical peptides in C57BL/6 mice. Brown adipose tissue, cerebral cortex, liver, lymph nodes, and serum were analyzed at 1, 6, 12, 18, and 24 months of age using data-independent acquisition mass spectrometry (DIA-MS). An expanded p...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-16 | PXD082651 | Pride
Short open reading frames Dia-ms Development C57bl/6 mice Non-canonical peptides Lifespan Multi-tissue proteomics Aging 
UnknownIdentification of non-canonical peptides with moPepGen.
Not available
S-EPMC10996593 | biostudies-literature
UnknownIdentification of non-canonical peptides with moPepGen.
Not available
S-EPMC12680078 | biostudies-literature
Proteomicsnon-canonical HLA peptides in cancer
Efforts to precisely identify tumor human leukocyte antigen presented peptides (HLAp) capable of mediating T cell based tumor rejection still face important challenges. Recent reports suggest that non-canonical cancer HLAp could be immunogenic but their identification requires highly sensitive and a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2026-02-16 | MSV000100859 | MassIVE
ProteomicsDiscovery of non-canonical translation initiation sites through mass spectrometric analysis of protein N-termini
Translation initiation generally occurs at AUG codons in eukaryotes although it has been shown that non-AUG or non-canonical translation initiation can also occur. However, the evidence for non-canonical translation initiation sites (TISs) is largely indirect and based on ribosome profiling studies....
ORGANISM(S): Homo sapiens (Human) 
2017-11-23 | PXD006633 | Pride
Human Non-canonical Tails 
ProteomicsNeoantigen Discovery and Validation in Hepatocellular Carcinoma: Unveiling Immunogenic Targets Through Mass Spectrometry
The accurate identification of tumor neoantigens, particularly cryptic antigens from non-canonical translation, is crucial for developing effective cancer immunotherapies. However, the significance and action of cryptic antigens in anti-tumour immunity remain unclear. In this study, we utilized a hi...
ORGANISM(S): Rattus Rattus 
2025-07-25 | PXD079354 |
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