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GenomicsAtaxin-2, Twenty-four and Dicer-2 are components of a non-canonical cytoplasmic polyadenylation complex
Ataxin-2, Twenty-four and Dicer-2 are components of a non-canonical cytoplasmic polyadenylation complex
PRJNA784931 | ENA
TranscriptomicsPombe_polyA_mapping_NGS_v3
Regulatory elements in the 3M-^R untranslated regions (UTRs) of eukaryotic mRNAs influence mRNA localization, translation, and stability. The length of these regions is determined by the location at which mRNAs are cleaved and polyadenylated. The use of alternative polyadenylation sites is common,...
ORGANISM(S): Schizosaccharomyces pombe 
2013-11-19 | E-MTAB-1642 | biostudies-arrayexpress
ProteomicsThe non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
FAM46C is one of the most frequently mutated genes in multiple myeloma (MM). Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C ...
ORGANISM(S): Homo sapiens (Human) 
2018-03-09 | PXD006790 | Pride
Lc-msms Fam46c Anemia Mouse B lymphocytes Polyadenylation Multiple myeloma 
TranscriptomicsAtaxin-2, Twenty-four and Dicer-2 are components of a non-canonical cytoplasmic polyadenylation complex
Cytoplasmic polyadenylation is a mechanism to promote mRNA translation in a wide variety of biological contexts. A canonical complex centered around the conserved RNA-binding protein family CPEB has been shown to be responsible for this process. We have previously reported evidence for an alternativ...
ORGANISM(S): Drosophila melanogaster 
2022-08-29 | GSE189868 | GEO
GenomicsThe non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice
The non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice
PRJNA511026 | ENA
UnknownEssential role for non-canonical poly(A) polymerase GLD4 in cytoplasmic polyadenylation and carbohydrate metabolism.
Not available
S-EPMC5499868 | biostudies-literature
ProteomicsTENT5 cytoplasmic non-canonical poly(A) polymerases regulate the innate immune response in animals
Innate immunity, the first line of host defense against pathogens, is tightly regulated both transcriptionally and post-transcriptionally. Here, through global transcriptome and proteome analyses in Caenorhabditis elegans, we uncover a modulation of the expression of secreted innate immunity effecto...
ORGANISM(S): Caenorhabditis elegans 
2022-05-31 | PXD023238 | Pride
Innate immunity Cytoplasmic polyadenylation Non-canonical polyadenylation Tent5 Direct rna sequencing Terminal nucleotidyltransferase C. elegans innate immunity 
UnknownA Putative TRAPα Protein of Microsporidia Nosema bombycis Exhibits Non-Canonical Alternative Polyadenylation in Transcripts.
Not available
S-EPMC10142623 | biostudies-literature
UnknownNon-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses.
Not available
S-EPMC11019558 | biostudies-literature
UnknownSplicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals.
Not available
S-EPMC1888663 | biostudies-literature
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