Sort   by:  
 Page size 
MetabolomicsTowards engineering ectomycorrhization into switchgrass bioenergy crops via a lectin receptor-like kinase
Soil-borne microbes can establish compatible relationships with host plants, providing a large variety of nutritive and protective compounds in exchange for photosynthesized sugars. However, the molecular mechanisms mediating the establishment of these beneficial relationships remain unclear. Our pr...
2021-08-11 | MTBLS2597 | MetaboLights
ProteomicsPhosphoproteomics analysis identifies novel candidate substrates of the non-receptor tyrosine kinase, SRMS
SRMS (Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites) or PTK 70 (Protein tyrosine kinase 70) is a non-receptor tyrosine kinase that belongs to the BRK family kinases (BFKs). The gene encoding SRMS was first discovered in 1994. Yet to date less is known ...
ORGANISM(S): Homo sapiens (Human) 
2018-03-08 | PXD006809 | Pride
Frk Srms Substrates Brk Mass spectrometry Ptk6 Src Phosphoproteomics Ptk 70 
TranscriptomicsThe RON receptor tyrosine kinase promotes metastasis by triggering epigenetic reprogramming through the thymine glycosylase MBD4 (RNA-Seq)
Metastasis is the major cause of death in cancer patients, yet the genetic/epigenetic programs that drive metastasis are poorly understood. Here, we report a novel epigenetic reprogramming pathway that is required for breast cancer metastasis. Concerted differential DNA methylation is initiated by a...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-52687 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of the MLL-AF4 and Flt3 tyrosine kinase domain (TKD) genes in 32Dc cell
The tumorigenesis capacity of MLL-AF4 alone is insufficient for causing leukemia. Based on the finding that an Flt3 gene mutation in the tyrosine kinase domain (TKD) was observed in approximately 15% of MLL leukemia, we investigated synergistic leukemogenesis effects of the two genes in vitro. In a ...
ORGANISM(S): Mus musculus 
2009-03-31 | E-GEOD-14236 | biostudies-arrayexpress
TranscriptomicsA receptor tyrosine kinase network comprised of FGFRs, EGFR, ERBB2, and MET drives growth and survival of HNSCC cell lines.
We have previously shown that some gefitinib insensitive head and neck squamous cell carcinoma (HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor receptor (FGFR) signaling. Herein, we deployed a whole genome loss-of-function screen to identify genes whose knockdown potentiated th...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-39305 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 32Dcl3 cell lines expressing oncogenic tyrosine kinases or cells treated with small molecule inhibitors
Oncogenic tyrosine kinases, such as BCR-ABL, TEL-ABL, TEL-PDGF-beta-R and FLT3-ITD, play a major role in the development of hematopoietic malignancy. They activate many of the same signal transduction pathways. To identify the critical target genes required for transformation in hematopoietic cells...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-11794 | biostudies-arrayexpress
TranscriptomicsThe RON receptor tyrosine kinase promotes metastasis by triggering epigenetic reprogramming through the thymine glycosylase MBD4 (gene expression array)
Metastasis is the major cause of death in cancer patients, yet the genetic/epigenetic programs that drive metastasis are poorly understood. Here, we report a novel epigenetic reprogramming pathway that is required for breast cancer metastasis. Concerted differential DNA methylation is initiated by a...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-52567 | biostudies-arrayexpress
ProteomicsIdentifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry
Mass spectrometry‐based in vitro kinase screens play an essential role in the discovery of kinase substrates, however, many suffer from biological and technical noise or necessitate genetically‐altered enzymecofactor systems. We describe a method that combines stable γ‐[18O2]‐ATP with classical in v...
ORGANISM(S): Homo sapiens (Human) 
2018-10-17 | PXD002133 | Pride
Human Kinase substrates  in vitro kinase assay  proteomics  mass spectrometry  heavy atp  non receptor tyrosine kinase abl1 
ProteomicsTyrosine phosphoproteomics of patient-derived xenografts reveals ephrin type-B receptor 4 tyrosine kinase as novel therapeutic target in pancreatic cancer
Pancreatic ductal adenocarcinoma is a recalcitrant tumor with minimal response to conventional chemotherapeutic approaches. Oncogenic signaling by activated tyrosine kinases has been implicated in cancers resulting in activation of diverse effector signaling pathways. Thus, discovery of aberrantly a...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-05-24 | PXD021729 | Pride
Receptor tyrosine kinase Ptyr Pdx Signaling Cancer 
ProteomicsSynergistic targeting of DNA-PK and KIT signaling pathways in KIT mutant acute myeloid leukemia
Acute Myeloid Leukemia (AML) is the most common and aggressive form of acute leukemia, with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating mutations in kinases, such as the receptor tyrosine kinases FLT3 and KIT. FLT3 and KIT mutations are associated with poor...
ORGANISM(S): Mus Musculus 
2023-01-26 | PXD030214 | panorama
Sort   by:  
 Page size