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ProteomicsAdrenergic Signaling and Proteomic Responses in Breast Cancer Spheroids: Implications for Tumor Microenvironment and Therapeutic Strategies
Breast cancer, a global health challenge, exhibits molecular heterogeneity and complex interactions with the tumor microenvironment. We investigated adrenergic modulation in breast cancer spheroids, differentiating between basal-like (MDA-MB-231 and BT549) and luminal-like (T47D and MCF-7) subtypes....
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD046841 | Pride
Breast cancer Proteomics Propranolol Noradrenalin Cancer Adrenergic signaling 
UnknownAntagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin.
Not available
S-EPMC5478265 | biostudies-literature
UnknownTerlipressin versus placebo or noradrenalin in the treatment of hepatorenal syndrome: a systematic review and meta-analysis.
Not available
S-EPMC11408352 | biostudies-literature
UnknownVal158Met polymorphisms of COMT gene and serum concentrations of catecholaminergic neurotransmitters of ADHD in Chinese children and adolescents.
Not available
S-EPMC8663844 | biostudies-literature
UnknownPhospholipase C-related but catalytically inactive protein (PRIP) modulates synaptosomal-associated protein 25 (SNAP-25) phosphorylation and exocytosis.
Not available
S-EPMC3322965 | biostudies-literature
UnknownIncreased very low frequency pulsations and decreased cardiorespiratory pulsations suggest altered brain clearance in narcolepsy.
Not available
S-EPMC9525269 | biostudies-literature
UnknownOctopamine and Tyramine Contribute Separately to the Counter-Regulatory Response to Sugar Deficit in Drosophila.
Not available
S-EPMC5775261 | biostudies-literature
TranscriptomicsLocus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer's disease
Alzheimer's disease (AD) often begins with non-cognitive symptoms such as olfactory deficits, which can predict later cognitive decline, though the mechanisms remain unclear. Pathologically, the brainstem locus coeruleus (LC), the main source of the neurotransmitter noradrenalin (NA) modulating olfa...
ORGANISM(S): Mus musculus 
2025-07-21 | GSE302245 | GEO
UnknownA mechanism-based proof of concept study on the effects of duloxetine in patients with painful knee osteoarthritis.
Not available
S-EPMC8710922 | biostudies-literature
TranscriptomicsIslet Sympathetic Innervation and Islet Neuropathology in Patients with Type 1 Diabetes
Dysregulation of glucagon secretion in type 1 diabetes (T1D) involves hypersecretion during postprandial states, but insufficient secretion during hypoglycemia. The sympathetic nervous system regulates glucagon secretion. To investigate islet sympathetic innervation in T1D, sympathetic tyrosine hydr...
ORGANISM(S): Homo sapiens 
2021-08-09 | GSE181674 | GEO
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