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TranscriptomicsFitness Landscape of Antibiotic Tolerance in Pseudomonas aeruginosa Biofilms
Bacteria in biofilms have higher antibiotic tolerance than their planktonic counterparts. A major outstanding question is the degree to which the biofilm-specific cellular state and its constituent genetic determinants contribute to this hyper-tolerant phenotype. Here, using genome-wide functional...
ORGANISM(S): Pseudomonas aeruginosa 
2011-11-21 | E-GEOD-26142 | biostudies-arrayexpress
ProteomicsPredictive Signatures of 19 Antibiotic-Induced Escherichia coli Proteomes
Identifying the mode of action (MOA) of antibacterial compounds is the fundamental basis for the development of new antibiotics, and the challenge increases with the emerging secondary and indirect effect from antibiotic stress. Although various omics-based system biology approaches are currently av...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2020-10-09 | MSV000086253 | MassIVE
MetabolomicsGlutamate-mediated metabolic rewiring boosts CpxA/R-OmpF porin and proton motive force to resensitize antibiotic-resistant Escherichia coli to ceftazidime

Ceftazidime (CAZ) is a critically important broad-spectrum antibiotic widely used in clinical practice. However, the rapid emergence of bacterial resistance to CAZ poses a significant challenge in treating infections caused by multidrug-resistant pathogens. In this study, we employed a metabolism...

2026-01-20 | MTBLS13732 | MetaboLights
MetabolomicsLuteolin as a urease inhibitor: a novel therapeutic strategy against Helicobacter pylori

The rising prevalence of antibiotic-resistant Helicobacter pylori (H. pylori) underscores the urgent need for alternative treatment strategies. By producing ammonia to neutralize gastric acid, the key virulence factor urease is essential for H. pylori&nbs...

2026-02-28 | MTBLS13581 | MetaboLights
TranscriptomicsMetabolic modeling of antibiotic and cytotoxic effects of the isoquinoline IQ-238 in S. aureus, S. epidermidis and human cells
Isoquinolines (IQs) are natural substances with antibiotic potential. IQ-238 is a synthetic analog of the novel-type N,C-coupled naphtylisoquinoline (NIQ) alkaloid ancisheynine. Gene expression data, cytotoxicity measurements and metabolic modelling is combined to assess the effects of the N,C-coup...
ORGANISM(S): Staphylococcus aureus 
2015-04-30 | E-GEOD-33832 | biostudies-arrayexpress
GenomicsA novel antibiotic resistance mechanism
A novel antibiotic resistance mechanism
PRJEB25942 | ENA
MetabolomicsA novel micro-voltage driven fungal system for simultaneous removal of microplastics, antibiotics, and heavy metals

Microplastics, antibiotics, and heavy metals are co-occurring pollutants in wastewater, posing significant environmental risks and potential threats to human health. However, there is currently no effective wastewater treatment method for this type of combined pollution. This study establishes a ...

2026-01-05 | MTBLS13609 | MetaboLights
TranscriptomicsA compendium of antibiotic-induced transcription profiles reveals broad regulation of P. multocida virulence genes
Treatment of bacteria with antibiotics at or close to the inhibitory concentration leads to specific transcriptional responses often affecting target genes and targets pathways. A dataset of transcriptional profiles (compendium) induced by antibiotics with known mode-of-action (MoA) can be used to g...
ORGANISM(S): Pasteurella multocida 
2008-06-01 | E-GEOD-10051 | biostudies-arrayexpress
TranscriptomicsPlasticity of transcriptional regulation under antibiotic stress
Evolution of antibiotic resistance in microbes is frequently achieved by acquisition of spontaneous mutations during antimicrobial therapy. Here we demonstrate that inactivation of a central regulator of iron homeostasis (fur) facilitates laboratory evolution of ciprofloxacin resistance in Escherich...
ORGANISM(S): Escherichia coli K-12 
2014-09-11 | E-GEOD-55662 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways
The eubacterial species Streptomyces coelicolor proceeds through a complex growth cycle in which morphological differentiation/development is associated with a transition from primary to secondary metabolism and the production of antibiotics. We used DNA microarrays and mutational analysis to invest...
ORGANISM(S): Streptomyces coelicolor 
2005-07-23 | E-GEOD-2983 | biostudies-arrayexpress
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